期刊
SLEEP
卷 43, 期 3, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsz237
关键词
RBD; REM sleep without atonia; PTSD; TBI; trauma-associated sleep disorder
资金
- U.S. Department of Veterans Affairs [1K2 RX002947, 1K2 BX002712]
- NIH EXITO Institutional Core [UL1GM118964]
- Portland VA Research Foundation
- National Institutes of Health [T32 AT002688]
- VA OAA Post-doctoral Nursing Research Fellowship
- VA Portland Health Care System
Study Objectives: To describe the crude prevalence of rapid eye movement (REM) sleep behavior disorder (RBD) following traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) in Veterans, given potential relationships between TBI, PTSD, RBD, and neurodegeneration. Methods: Veterans (n = 394; 94% male; 54.4 +/- 15.5 years of age) were prospectively/cross-sectionally recruited from the VA Portland Health Care System and completed in-lab video-polysomnography and questionnaires. TBI and PTSD were assessed via diagnostic screening and medical record review. Subjects were categorized into four groups after assessment of REM sleep without atonia (RSWA) and self-reported dream enactment: (1) Normal, neither RSWA nor dream enactment, (2) Other Parasomnia, dream enactment without RSWA, (3) RSWA, isolated-RSWA without dream enactment, and (4) RBD, RSWA with dream enactment. Crude prevalence, prevalence odds ratio, and prevalence rate for parasomnias across subjects with TBI and/or PTSD were assessed. Results: Overall prevalence rates were 31%, 7%, and 9% for Other Parasomnia, RSWA, and RBD, respectively. The prevalence rate of RBD increased to 15% in PTSD subjects [age adjusted POR: 2.81 (1.17-4.66)] and to 21% in TBI + PTSD subjects [age adjusted POR: 3.43 (1.20-9.35)]. No subjects met all diagnostic criteria for traumaassociated sleep disorder (TASD), and no overt dream enactment was captured on video. Conclusions: The prevalence of RBD and related parasomnias is significantly higher in Veterans compared with the general population and is associated with PTSD and TBI + PTSD. Considering the association between idiopathic-RBD and synucleinopathy, it remains unclear whether RBD (and potentially TASD) associated with PTSD or TBI + PTSD similarly increases risk for long-term neurologic sequelae.
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