PtW/MoS2 hybrid nanocomposite for electrochemical sensing of H2O2 released from living cells

Hydrogen peroxide (H2O2) as an important reactive oxygen species (ROS) is reactive and potentially harmful to cells, causing oxidation of lipids, proteins and DNA. Herein, we report a PtW/MoS2 hybrid nanocomposite with ultrasensitive and highly specific response for the detection of H2O2 released from breast cancer 4T1 cells. Upon exposure to 5 nM of H2O2, the electrochemical response is still visible. This PtW/MoS2 hybrid nanocomposite could be facilely synthesized through in-situ growth of PtW nano crystals on the surface of MoS2 nanosheets. The incorporation of PtW nanocrystals and MoS2 nanosheets in conjunction with each other to form hybrid nanocomposite improves the selective interaction of H2O2 with sensing material surface, and further increases the sensitivity and selectivity of sensor. (C) 2016 Elsevier B.V. All rights reserved.