期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 298, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.126903
关键词
Alzheimer's disease; Beta-amyloid; Viscosity; Dual-functional; Fluorescent probe; Merocyanine; Dye
资金
- Natural Science Foundation of Guangdong Province, China [2016A030310463]
- National Natural Science Foundation of China [21502056]
- Medical Scientific Re-search Foundation of Guangdong Province, China [A2018080]
A series of dual-functional red-emitting fluorescent probes were rationally designed, synthesized and evaluated through the introduction of amine chains based on a neutral merocyanine dye (MC-1) for in vivo imaging of beta-amyloid plaques as well as viscosity at cellular level. After optimization, the MC-N derivatives with higher fluorescence quantum yield and rational Log P showed high sensitivity to the surrounding environment and A beta aggregates. Besides, the MC-N derivatives can distinguish A beta plaques and viscosity changes through differences in the emission wavelengths in different environments. In vivo NIRF imaging demonstrated that the probe MC-N-2 was capable of readily penetrating the blood-brain barrier and efficiently made a distinction between transgenic and wild type mice at a low injection dosage (0.1 mg/kg).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据