A novel peroxidase mimetic Co-MOF enhanced luminol chemiluminescence and its application in glucose sensing

In this work, a metal organic framework material ([Co(L)(H2O)(2)](n), Co-MOF) was synthesized by a facile hydrothermal method, and it was found that Co-MOF have a peroxidase-like activity. They can efficiently catalyze the chemiluminescence (CL) reaction between luminol and H2O2 and enhance the CL signal significantly. The possible enhancement mechanism suggested that Co-MOF catalyzed the decomposition of H2O2 into O-2 and increased the generation of center dot O-2(-). Based on these findings, a new highly sensitive glucose sensor was constructed combined with the luminol-H2O2-Co-MOF CL system and glucose oxidase. Under the optimal conditions, the method exhibited a good linear response to glucose in the range of 0.04(similar to)8 mu M with a detection limit of 1 x 10(-8) M. The method has been further applied in the quantitative determination of glucose in human serum and urine successfully.