Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy

Despite considerable advances in the application of liposomal drug delivery systems in cancer treatment, the clinical application of liposomal formulations has been limited by many factors. It seems that there is a wide gap between results of experimental studies and clinical application of liposomes. In this review, we discuss barriers which limit the translation of liposomal delivery systems in cancer therapy. The main focus of this review will be on differences between preclinical and clinical studies and potential approaches to overcome the main pitfalls in the clinical application of liposomal delivery systems.

Automated summary

This review highlights the challenges in translating liposomal delivery systems from preclinical studies to clinical application in cancer therapy. The gap between experimental results and practical use of liposomes is a major concern that needs to be addressed in order to improve the efficacy of this drug delivery system. Various potential approaches to overcome the barriers in clinical application of liposomal formulations are also discussed.