Electrochemical acetylcholinesterase biosensor based on ZnO nanocuboids modified platinum electrode for the detection of carbosulfan in rice

The consumption of carbosulfan-contaminated rice affects the immune and lymphocyte response, germinal centers in the spleen, plasma cells in popliteal lymphoid nodes, bone marrow cells and granulocyte-macrophage progenitor cells. Towards this, a highly sensitive acetylcholinesterase (AChE) cyclic voltammetric biosensor based on zinc oxide (ZnO) nanocuboids modified platinum (Pt) electrode has been successfully developed. The Pt/ZnO/AChE/Chitosan bio-electrode was employed for the electrochemical detection of carbosulfan in rice sample. Under optimum conditions, the Pt/ZnO/AChE/Chitosan bio-electrode detected carbosulfan ranging from 5 to 30 nM with a detection limit (LOD) of 0.24 nM. The developed Pt/ZnO/AChE/Chitosan bio-electrode showed good recovery (99.06-100.96%), thus providing a promising tool for analysis of carbosulfan in rice sample. (C) 2015 Elsevier B.V. All rights reserved.