4.7 Article

High-performance liquid chromatography (HPLC)-fluorescence method for determination of bisphenol A diglycidyl ether (BADGE) and its derivatives in canned foods

期刊

SCIENCE OF THE TOTAL ENVIRONMENT
卷 710, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.scitotenv.2019.134975

关键词

Bisphenol A diglycidyl ether (BADGE); HPLC; Core-shell particle column; Canned foods

资金

  1. National Key Research and Development Program, China [2018YFD0400700, 2016YFD0400301]
  2. Fundamental Research Funds for the Central Universities, China [172210181]
  3. Key Research and Development Program of Zhejiang Province, China [2017C02015]

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Bisphenol A diglycidyl ether (BADGE) is used as a raw material for the production of epoxy resins and PVC organosols, which are commonly applied as inner coatings for food cans. BADGE and its derivatives can migrate from coatings to foodstuffs during processing and storage thereby creating adverse health issues. In this work, a method based on high-performance liquid chromatography (HPLC)-fluorescence detection (FLD) method was developed for the rapid determination of BADGE and its five derivatives in canned foods. Modeling software DryLab (R) was applied for the optimization of separation conditions. An adequate separation was achieved in 5 min including equilibration time, using a core-shell particle column; such application has not been reported so far. Also, the results showed that LOD varied from 0.01 to 0.20 ng/g, while LOQ varied from 0.03 to 0.66 ng/g, and RSD was found to be <8.64%. The analytical recoveries ranged from 70.46 to 103.44%. Excellent validation data revealed that this method is suitable for the investigation of can coating-to-food migration of BADGE and its derivatives. The HPLC-FLD method is rapid, inexpensive and highly efficient, which could be applicable for safety inspection of food contact materials involving BADGE and its derivatives. (C) 2019 Elsevier B.V. All rights reserved.

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