4.7 Article

Shape-dependent toxicity of alumina nanoparticles in rat astrocytes

期刊

SCIENCE OF THE TOTAL ENVIRONMENT
卷 690, 期 -, 页码 158-166

出版社

ELSEVIER
DOI: 10.1016/j.scitotenv.2019.06.532

关键词

Nanoparticles; Morphology; Brain; Inflammation; Oxidative stress; Apoptosis; Untargeted metabolomics; Pathway analysis

资金

  1. National Natural Science Foundation of China [81372949, 21707132]
  2. Young Scholar Scientific Research Foundation from China CDC [2018A201]
  3. NIEH, China CDC
  4. High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China [GDT20143200016]
  5. Einstein Professor Program of the Chinese Academy of Sciences
  6. Department of Environmental Sciences at Baylor University, Waco, Texas, USA
  7. Canada Research Chairs program

向作者/读者索取更多资源

Nanosized alumina (Al2O3-NPs), a widely used nanoparticle in numerous commercial applications, is released into environment posing a threat to the health of wildlife and humans. Recent research has revealed essential roles of physicochemical properties of nanoparticles in determining their toxicity potencies. However, influence of shape on neurotoxicity induced by heterogeneous Al2O3 -NPs remains unknown. We herein compared the neurotoxicity of two shapes of gamma-Al2O3-NPs (flake versus rod) and their effects on metabolic profiles of astrocytes in rat cerebral cortex. While exposed to both shapes caused significant cytotoxicity and apoptosis in a dose-dependent manner after 72 h exposure, a significantly stronger response was observed for nanorods than for nanoflakes. These effects were associated with significantly greater ROS accumulation and inflammation induction, as indicated by increased concentrations of IL-1 beta, IL-2 and IL-6. Using untargeted metabolomics, significant alternations in metabolism of amino adds, lipids and purines, and pyrimidines were observed after exposure to both types. Moreover, changes in the metabolome caused by nanorods were significantly greater than those by nanoflakes as also indicated by physiological stress responses to ROS, inflammation, and apoptosis. Taken together, these findings demonstrated the critical role of morphology in determining toxic potencies of nanoalumina and its underlying mechanisms of toxic actions. (C) 2019 Elsevier B.V. All rights reserved.

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