期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 689, 期 -, 页码 505-515出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2019.06.251
关键词
Birds; Developmental immunotoxicology; Diseases; immune function; Lead poisoning; Shot pellet
资金
- Spanish Ministry of Science and Innovation [BES-2011-045670, CGL2010-17030]
The ingestion of lead (Pb) shot pellets is a well-known cause of avian mortality, but exposure of birds to Pb may have other sublethal effects that can affect population sustainability. One of these effects is the alteration of the immunological status. Pb can affect most components of the avian immune system and imbalance the relationship among them. Pb exposure typically alters the ratio between T-h1- and T-h2-type responses mounted by different classes of T-lymphocytes, causing the depression of the T-h1 responses that are associated with cell-mediated immunity. Immunodepressing effects of Pb on birds are observed at blood levels above 50 mu g dL(-1), but developing birds show immunodepressing effects at much lower concentrations (> 10 mu g dL(-1)). Impacts of Pb on the avian immune system also relate to reduced resistance to infection. We review immunotoxic effects of Pb on birds affected by shot ingestion as well as by other sources of exposure to this element. (C) 2019 Elsevier B.V. All rights reserved.
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