期刊
SCIENCE
卷 366, 期 6467, 页码 822-826出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aax2957
关键词
-
资金
- Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research
- National Institutes of Health [R37 GM074593, R01 GM059614]
The numerous quality control pathways that target defective ribonucleic acids (RNAs) for degradation play key roles in shaping mammalian transcriptomes and preventing disease. These pathways monitor most steps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degrading ncRNAs that fail to form functional complexes with one or more proteins and eliminating mRNAs that encode abnormal, potentially toxic proteins. Mutations in components of diverse RNA surveillance pathways manifest as disease. Some mutations are characterized by increased interferon production, suggesting that a major role of these pathways is to prevent aberrant cellular RNAs from being recognized as non-self. Other mutations are common in cancer, or result in developmental defects, revealing the importance of RNA surveillance to cell and organismal function.
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