期刊
SCHIZOPHRENIA RESEARCH
卷 215, 期 -, 页码 167-172出版社
ELSEVIER
DOI: 10.1016/j.schres.2019.10.045
关键词
Schizophrenia; Microglia; Post-mortem; TSPO; PET imaging; Neuroinflammation
类别
资金
- Netherlands Organization for Scientific Research (NWO) [1212154]
- 2014 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation
- psychiatric donor program of the Netherlands Brain Bank (NBB-Psy)
- Netherlands Organization for Scientific Research (NWO)
Positron emission tomography (PET) with translocator 18 kDa protein (TSPO) radioligands has frequently been used to investigate microglial activation in schizophrenia in vivo. However, the specificity of this marker is increasingly debated. Here we show that TSPO expression is 1) not increased in postmortem brain tissue of schizophrenia patients; 2) not correlated with expression of microglial activation markers; 3) not restricted to microglia; and 4) not upregulated in ex vivo activated human primary microglia. Our data are in line with recent reports showing that TSPO expression is not increased in schizophrenia and that it is not a specific marker for activated microglia. This study emphasizes the need for further development of tracers to study the role of microglial activation in schizophrenia and other diseases. (C) 2019 Elsevier B.V. All rights reserved.
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