期刊
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
卷 20, 期 3, 页码 263-272出版社
SPRINGER
DOI: 10.1007/s11154-019-09515-x
关键词
Obesity; fMRI; Neuroimaging; Impulsivity; Compulsivity; Neuroendocrinology
资金
- Department of Health of the Generalitat de Catalunya by the call Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut [SLT006/17/00246]
- Instituto de Salud Carlos III [PI17/01167, PI13/01958, PI16/00889]
- EU (H2020
- Eat2beNICE) [728,018]
- 'Miguel Servet' contract from the Carlos III Health Institute [CPII16/00048]
Impulsivity and compulsivity are multidimensional constructs that are increasingly considered determinants of obesity. Studies using functional magnetic resonance imaging (fMRI) have provided insight on how differences in brain response during tasks exploring facets of impulsivity and compulsivity relate to the ingestive behaviors that support the etiology and maintenance of obesity. In this narrative review, we provide an overview of neuroimaging studies exploring impulsivity and compulsivity factors as they relate to weight status. Special focus will be placed on studies examining the impulsivity-related dimensions of attentional bias, delayed gratification and emotion regulation. Discussions of compulsivity within the context of obesity will be restricted to fMRI studies investigating habit formation and response flexibility under shifting contingencies. Further, we will highlight neuroimaging research demonstrating how alterations in neuroendocrine functioning are linked to excessive food intake and may serve as a driver of the impulsive and compulsive behaviors observed in obesity. Research on the associations between brain response with neuroendocrine factors, such as insulin, peptide YY (PYY), leptin, ghrelin and glucagon-like peptide 1 (GLP-1), will be reviewed.
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