期刊
REGENERATIVE MEDICINE
卷 14, 期 10, 页码 955-967出版社
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2019-0098
关键词
Cutibacterium acnes; Propionibacterium acnes; anti-infective; antimicrobial; disc degeneration; intervertebral disc; leukocyte; low back pain; neutrophil; platelet-rich plasma; regenerative medicine
资金
- Regenerative SportsCare Foundation
- EmCyte Corporation
Aim: The most common risk associated with intradiscal injection of platelet-rich plasma (PRP) is discitis with Cutibacterium acnes. It is hypothesized that antimicrobial activity of PRP can be enhanced through inclusion of leukocytes or antibiotics in the injectate. Materials & methods: Multiple PRP preparations of varying platelet and leukocyte counts were co-cultured with C. acnes with or without cefazolin, with viable bacterial colony counts being recovered at 0, 4, 24 and 48 hours post-inoculation. Results: A direct correlation between C. acnes recovery and granulocyte counts were observed. Conclusion: We observed the greatest antimicrobial activity with the leukocyte-rich, high platelet PRP preparation combined with an antibiotic in the injectate. However, cefazolin did not completely clear the bacteria in this assay.
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