期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 80, 期 7, 页码 1283-1293出版社
OXFORD UNIV PRESS
DOI: 10.1080/09168451.2016.1151344
关键词
secondary metabolites; self-tolerance; transporter; transport engineering
类别
资金
- Japan Society for the Promotion of Science (JSPS KAKENHI) [25712012]
- Grants-in-Aid for Scientific Research [25712012] Funding Source: KAKEN
Plants produce a host of secondary metabolites with a wide range of biological activities, including potential toxicity to eukaryotic cells. Plants generally manage these compounds by transport to the apoplast or specific organelles such as the vacuole, or other self-tolerance mechanisms. For efficient production of such bioactive compounds in plants or microbes, transport and self-tolerance mechanisms should function cooperatively with the corresponding biosynthetic enzymes. Intensive studies have identified and characterized the proteins responsible for transport and self-tolerance. In particular, many transporters have been isolated and their physiological functions have been proposed. This review describes recent progress in studies of transport and self-tolerance and provides an updated inventory of transporters according to their substrates. Application of such knowledge to synthetic biology might enable efficient production of valuable secondary metabolites in the future.
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