期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 80, 期 6, 页码 1066-1069出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2016.1148581
关键词
callipeltin; cytotoxicity; cyclic depsipeptides
类别
资金
- Japan Society for the Promotion of Science Fellowships for young scientists [8696]
- Japan Society for the Promotion of the Science [25450145]
- Grants-in-Aid for Scientific Research [16K07709, 25450145] Funding Source: KAKEN
The cytotoxic evaluation of natural and synthetic callipeltins is described. Cyclic depsipeptide callipeltin B and linear peptides callipeltins E and M synthesized by us showed no cytotoxic activity. In contrast, natural callipeltin B purified from Callipelta sp. showed CC50 = 130 mu M against Hela cells. We found that purified callipeltin B included the contamination of callipeltins C and H at a ratio of approximately 15%. These results suggested that the cytotoxicity of natural callipeltin B was derived from callipeltins C and H.
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