期刊
PSYCHOPHARMACOLOGY
卷 237, 期 1, 页码 263-278出版社
SPRINGER
DOI: 10.1007/s00213-019-05364-3
关键词
Alcohol; Impulsivity; Delay discounting; Probability discounting; Craving; Relapse
资金
- National Institute on Alcohol Abuse and Alcoholism [T32 AA007468, R21AA020039]
- Department of Veterans Affairs Clinical Sciences Research and Development Merit Review Program [I01 CX001558-01A1]
- Department of Justice [2010-DD-BX-0517]
- National Institute on Drug Abuse [T32 DA007262, P50DA018165]
- Oregon Clinical and Translational Research Institute
- National Center for Research Resources, a component of the National Institutes of Health [1 UL1 RR024140 01]
- National Institute of Health Roadmap for Medical Research
- Department of Veterans Affairs Clinical Sciences Research and Development Career Development Award [CX17008-CDA2]
- Oregon Health & Science University Collins Medical Trust [APSYC0249]
- Medical Research Foundation of Oregon [APSYC0250]
Rationale Alcohol-use disorder (AUD) is associated with the propensity to choose smaller sooner options on the delay discounting task. It is unclear, however, how inherent risk underlies delay discounting behavior. As impulsive choice is a hallmark feature in AUD, it is important to understand the neural response to reward and delay while accounting for risk in impulsive decision-making. Objective This study examined activation associated with delay and reward magnitude, while controlling for risk in a probabilistic delay discounting task in AUD and examined if differences in activation were associated with treatment outcomes. Methods Thirty-nine recently abstinent alcohol-dependent volunteers and 46 controls completed a probabilistic delay discounting task paired with functional magnetic resonance imaging. Alcohol use was collected using a self-report journal for 3 months following baseline scan. Results During delay stimulus presentations, Controls exhibited greater activation compared to the Alcohol group notably in the anterior insula, middle/dorsal anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (PFC), and inferior parietal lobule. For magnitude, the Alcohol group exhibited greater activation than Controls primarily in medial PFC, rostral ACC, left posterior parietal cortex, and right precuneus. Within the Alcohol group, alcohol craving severity negatively correlated with right lateral PFC activation during reward magnitude in individuals who completed the 3-month study without relapse, while non-completers showed the opposite relationship. Conclusions The results of this study extend previous findings that alcohol use disorder is associated with differences in activation during an immediate or delayed choice by delineating activation associated with the parameters of impulsive choice.
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