期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 80, 期 5, 页码 856-862出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2015.1136878
关键词
berberine; berberrubine; Rhodococcus sp; degradation; benzeneacetic acid analog
类别
资金
- Hoshi University [Otani Research Grants]
- Grants-in-Aid for Scientific Research [26221201] Funding Source: KAKEN
Based on the finding of a novel berberine (BBR)-utilizing bacterium, Rhodococcus sp. strain BD7100, we investigated the degradation of BBR and its analog berberrubine (BRU). Resting cells of BD7100 demethylenated BBR and BRU, yielding benzeneacetic acid analogs. Isolation of benzeneacetic acid analogs suggested that BD7100 degraded the isoquinoline ring of the protoberberine skeleton. This work represents the first report of cleavage of protoberberine skeleton by a microorganism.
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