期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 49, 页码 24760-24769出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1908128116
关键词
host-microbiome; ILC; Helicobacter; inflammation
资金
- NIH [AI132391, DK105562, 1S10 OD021676-01]
- Pew Charitable Trusts
- Burroughs Wellcome Fund
Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated ROR gamma t(+) group 3 ILCs (ILC3s), especially T-bet(+) ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host-microbe interactions that critically sustain the maintenance of intestinal ILC3s.
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