期刊
POLYMER
卷 180, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2019.121707
关键词
PLLA-based scaffolds; Structural manipulation; Sc-CO2 foaming; Degradability; Hydrophilicity; In vitro and in vivo
资金
- National Natural Science Foundation of China [51803062, 51573063]
- Natural Science Foundation of Guangdong Province [2018A030310379]
- Science and Technology Program of Guangzhou [201904010272]
Porous poly (L-lactic acid) (PLLA)-based tissue engineering scaffolds have gained growing interests due to their unique structures and properties. However, the simple and green fabrication of PLLA-based scaffolds with uniform and interconnected pore structure, good degradability and hydrophobicity, and excellent biocompatibility remain a major challenge. Herein, we developed a facile, cost-effective and eco-friendly structural manipulation processing with supercritical carbon dioxide (Sc-CO2) foaming technique to prepare porous PLLA/poly (ethylene glycol) (PEG) (95/5 wt%) scaffolds. First, structural manipulation processing was used to manipulate the formation of oriented crystal structure in a PLLA matrix, which could slow down the gas escaping during the Sc-CO2 foaming process. Subsequently, the Sc-CO2 foaming process was utilized to form 3D porous scaffolds, which are suitable for the cell growth, migration and proliferation. The fabricated porous biodegradable scaffold exhibited high porosity (90.3%), uniform and interconnected open-pores, good strengths (11.9 MPa/(g.cm(3))), degradabilities and hydrophilicities (75.7 +/- 2.1 degrees), as well as excellent in vitro biocompatibilities. For in vivo application, a rabbit model with bone defects was utilized, and both the histological analysis and immunohistochemical analysis results revealed that the obtained porous PLLA/PEG scaffolds support bone tissue engineering.
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