期刊
POLYCYCLIC AROMATIC COMPOUNDS
卷 41, 期 8, 页码 1608-1622出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10406638.2019.1689514
关键词
Antitumor agents; Imidazo[21-b]thiazole; Thiazole; Thiosemicarbazones; Thiocarbohydrazide
The study synthesized four new series of thiazolylimidazothiazole derivatives and characterized their structures, evaluating their activity against human cancer cells in vitro. The promising results suggest the potential for further investigation into these novel compounds.
Based on the search for new heterocyclic drugs suitable as anticancer agents and our knowledge of the efficacy of thiazol and imidazothiazole derivatives as anticancer drugs, we have created four new series of thiazolylimidazothiazole derivatives from the reaction of each of imidazothiazole-thiosemicabazone and imidazothiazole-thicarbohydrazone derivatives with acetyl-hydrazonoyl chlorides and ester-hydrazonoyl chlorides in dioxane/drops of Et3N. The structure of the four novel series of thiazolylimidazothiazoles was characterized by physical and spectroscopic tools. In addition, all the newly synthesized derivatives were examined in vitro for their activity against HCT-116 and MCF-7 human cancer cells using the MTT assay to evaluate their pharmaceutical importance. The encouraging potent results observed from anticancer elusidation studies on the newly prepared thiazolylimidazothiazole derivatives make the design and synthesis of novel series of these systems and studying of their pharmaceutical importance an active zone for more and more investigations.
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