期刊
PLANTA MEDICA
卷 86, 期 1, 页码 45-54出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1023-7385
关键词
Sargassaceae; Sargassum serratifolium; lipolysis; sargaquinoic acid; adipocytes
资金
- project Development of nutraceuticals from Sargassum serratifolium - Ministry of Oceans and Fisheries, Republic of Korea [20150311]
A previous study showed that the meroterpenoid-rich fraction of an ethanolic extract of Sargassum serratifolium (MES) stimulated adipose tissue browning and inhibited diet-induced obesity and metabolic syndrome. Sargaquinoic acid (SQA) is a major component in MES. We investigated the effects of SQA on the differentiation of preadipocytes to the beige adipocytes. SQA was treated in 3T3-L1 adipocytes differentiated under a special condition that has been reported to induce the browning of adipocytes. SQA at 10 mu M reduced lipid accumulation by approximately 23%. SQA at 2.5 - 10 mu M induced the differentiation of white adipocytes to beige adipocytes partially by increasing the mitochondrial density and the expression of beige/brown adipocyte markers. In addition, SQA activated lipid catabolic pathways, evidenced by the increased expression levels of perilipin, carnitine palmitoyltransferase 1, and acyl-CoA synthetase long-chain family member 1. As a partial mechanism, biochemical and in silico analyses indicate that SQA activated AMP-activated protein kinase signaling in adipocytes.
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