相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Prostaglandins in asthma and allergic diseases
R. Stokes Peebles
PHARMACOLOGY & THERAPEUTICS (2019)
Erenumab: A First-in-Class Monoclonal Antibody for Migraine Prevention
Scott G. Garland et al.
ANNALS OF PHARMACOTHERAPY (2019)
Biased perspectives on formyl peptide receptors
Carsten Alexander Raabe et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)
Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs
Timo W. M. De Groof et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)
Characterization of cysteinyl leukotriene-related receptors and their interactions in a mouse model of asthma
Hoang Kim Tu Trinh et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2019)
Clinical efficacy and safety of anticholinergic therapies in pediatric patients
Stanley Goldstein
THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2019)
Caplacizumab as an emerging treatment option for acquired thrombotic thrombocytopenic purpura
Tugrul Elverdi et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2019)
Antibodies to watch in 2019
Helene Kaplon et al.
MABS (2019)
A Randomized Trial of Dual-Acting Bronchodilator AZD8871 for Chronic Obstructive Pulmonary Disease
Dave Singh et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)
The use of omalizumab in allergen immunotherapy
J. A. Dantzer et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2018)
Fevipiprant in the treatment of asthma
Christobelle White et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2018)
Progressive increase in allergen concentration abrogates immune tolerance in ovalbumin-induced murine model of chronic asthma
Gurupreet S. Sethi et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2018)
Leukotriene receptors as potential therapeutic targets
Takehiko Yokomizo et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Repeated Allergen Exposure in A/J Mice Causes Steroid-Insensitive Asthma via a Defect in Glucocorticoid Receptor Bioavailability
Magda F. Serra et al.
JOURNAL OF IMMUNOLOGY (2018)
Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β2-Adrenoceptor Agonists
Dong Yan et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)
After asthma: redefining airways diseases
Ian D. Pavord et al.
LANCET (2018)
Antibodies to watch in 2018
Helene Kaplon et al.
MABS (2018)
Structure and dynamics of GPCR signaling complexes
Daniel Hilger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
M. Castro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth
Raimond Heukers et al.
ONCOGENE (2018)
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor
Magdalena Korczynska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Asthma Endotyping and Biomarkers in Childhood Asthma
Amelia Licari et al.
PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY (2018)
Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma
Xianhai Huang et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis
Gulixian Mahemuti et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2018)
Efficacy and safety of the CRTh2 antagonist AZD 1981 as add-on therapy to inhaled corticosteroids and long-acting beta(2)-agonists in patients with atopic asthma
Eric D. Bateman et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2018)
Structure and dynamics of GPCR signaling complexes
Daniel Hilger et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets
Paul A. Insel et al.
FRONTIERS IN PHARMACOLOGY (2018)
Tiotropium: from COPD to young children with asthma?
Alvaro A. Cruz
LANCET RESPIRATORY MEDICINE (2018)
A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma
Alexa P. Kollmeier et al.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)
The mode of action of anticholinergics in asthma
Reinoud Gosens et al.
EUROPEAN RESPIRATORY JOURNAL (2018)
Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition
Lei Wang et al.
MOLECULAR CELL (2018)
Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial
Youn H. Kim et al.
LANCET ONCOLOGY (2018)
Single-Inhaler Triple versus Dual Therapy in Patients with COPD
Giovanni Rolla et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Tiotropium add-on to inhaled corticosteroids versus addition of long-acting β2-agonists for adults with asthma
Roland Buhl et al.
RESPIRATORY MEDICINE (2018)
A benchmarking study on virtual ligand screening against homology models of human GPCRs
Victor Jun Yu Lim et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2018)
Formyl-Peptide Receptors in Infection, Inflammation, and Cancer
Elisabeth Weiss et al.
TRENDS IN IMMUNOLOGY (2018)
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
Matthieu Masureel et al.
NATURE CHEMICAL BIOLOGY (2018)
Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor
Ryoji Suno et al.
NATURE CHEMICAL BIOLOGY (2018)
Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Hongtao Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Potential new targets for drug development in severe asthma
Linda Zhu et al.
WORLD ALLERGY ORGANIZATION JOURNAL (2018)
The prostaglandin D2 receptor 2 pathway in asthma: a key player in airway inflammation
Christian Domingo et al.
RESPIRATORY RESEARCH (2018)
The Economic Burden of Asthma in the United States, 2008-2013
Tursynbek Nurmagambetov et al.
ANNALS OF THE AMERICAN THORACIC SOCIETY (2018)
Inhaled short-acting bronchodilators for managing emergency childhood asthma: an overview of reviews
M. Pollock et al.
ALLERGY (2017)
GPCR Dynamics: Structures in Motion
Naomi R. Latorraca et al.
CHEMICAL REVIEWS (2017)
A comprehensive map of molecular drug targets
Rita Santos et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
CysLT2 receptor activation is involved in LTC4-induced lung air- trapping in guinea pigs
Tomohiko Sekioka et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2017)
Severe asthma: phenotyping to endotyping or vice versa?
Alberto Papi et al.
EUROPEAN RESPIRATORY JOURNAL (2017)
Fevipiprant, an oral prostaglandin DP2 receptor (CRTh2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroids
Eric D. Bateman et al.
EUROPEAN RESPIRATORY JOURNAL (2017)
Emerging inhaled long-acting beta-2 adrenoceptor agonists for the treatment of COPD
Thomas J. Monaco et al.
EXPERT OPINION ON EMERGING DRUGS (2017)
Umeclidinium for the treatment of uncontrolled asthma
Matteo Ferrando et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel CRTH2 Antagonist BI 1021958 at Single Oral Doses in Healthy Men and Multiple Oral Doses in Men and Women With Well-Controlled Asthma
Andy Fowler et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2017)
CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome
Raymond H. de Wit et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)
The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition
Hui-Qiong He et al.
MOLECULES (2017)
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
Xiangyu Liu et al.
NATURE (2017)
Single-molecule analysis of ligand efficacy in β2AR-G-protein activation
G. Glenn Gregorio et al.
NATURE (2017)
Structural insight into allosteric modulation of protease-activated receptor 2
Robert K. Y. Cheng et al.
NATURE (2017)
The cubicon method for concentrating membrane proteins in the cubic mesophase
Pikyee Ma et al.
NATURE PROTOCOLS (2017)
Opportunities for therapeutic antibodies directed at G-protein-coupled receptors
Catherine J. Hutchings et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Trends in GPCR drug discovery: new agents, targets and indications
Alexander S. Hauser et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
A Controlled Trial of Erenumab for Episodic Migraine
Peter J. Goadsby et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Nanobodies®† as inhaled biotherapeutics for lung diseases
Gino Van Heeke et al.
PHARMACOLOGY & THERAPEUTICS (2017)
β2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility
Long P. Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Effects of β-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype
Radhika Joshi et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2017)
Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma
Erwin W. Gelfand
SEMINARS IN IMMUNOLOGY (2017)
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma
David A. Sandham et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
Pauline Scholler et al.
NATURE COMMUNICATIONS (2017)
Development of New Therapies for Severe Asthma
Merritt L. Fajt et al.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2017)
Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry
Tom L. Blundell
IUCRJ (2017)
β2-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells
Andrew I. Ritchie et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)
Animal models of asthma: utility and limitations
Marcelo Vivolo Aun et al.
JOURNAL OF ASTHMA AND ALLERGY (2017)
Efficacy, safety, and tolerability of once-daily abediterol in patients with stable, persistent asthma: a Phase II, randomized, 7-day, crossover study
Jutta Beier et al.
PHARMACOLOGY RESEARCH & PERSPECTIVES (2017)
Structural Basis for G Protein-Coupled Receptor Activation
Aashish Manglik et al.
BIOCHEMISTRY (2017)
Asthma Endotypes and an Overview of Targeted Therapy for Asthma
Sarah Svenningsen et al.
FRONTIERS IN MEDICINE (2017)
Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma
Ruchong Chen et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)
ALX receptor ligands define a biochemical endotype for severe asthma
Isabell Ricklefs et al.
JCI INSIGHT (2017)
Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives
Maciej Kupczyk et al.
DRUGS (2017)
Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering
Xiaojie Yu et al.
BIODRUGS (2017)
A randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthma
David Miller et al.
ALLERGY AND ASTHMA PROCEEDINGS (2017)
Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study
Daniel R. Morales et al.
BMC MEDICINE (2017)
A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED
Chih-Hsi Scott Kuo et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)
Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications
D. Robinson et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2017)
New Therapies for Asthma and Chronic Obstructive Pulmonary Disease
Nicholas J. Gross et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)
From mouse to man: predicting biased effects of beta-blockers in asthma
B. J. Lipworth et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Barriers to new drug development in respiratory disease
Grania Brigden et al.
EUROPEAN RESPIRATORY JOURNAL (2016)
Epidemiology of asthma
Patricia A. Loftus et al.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY (2016)
Phenotyping and Endotyping Asthma Based on Biomarkers
Fotis Perlikos et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)
Drugging specific conformational states of GPCRs: challenges and opportunities for computational chemistry
Maria Marti-Solano et al.
DRUG DISCOVERY TODAY (2016)
Nanobodies as therapeutics: big opportunities for small antibodies
Sophie Steeland et al.
DRUG DISCOVERY TODAY (2016)
The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors
Jeffrey S. Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor
Xavier Peyrassol et al.
JOURNAL OF IMMUNOLOGY (2016)
Pulmonary Remodeling in Equine Asthma: What Do We Know about Mediators of Inflammation in the Horse?
Ann Kristin Barton et al.
MEDIATORS OF INFLAMMATION (2016)
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
Dean P. Staus et al.
NATURE (2016)
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
David M. Thal et al.
NATURE (2016)
Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy
Marta Calbet et al.
PHARMACOLOGICAL RESEARCH (2016)
Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones
Tonio Pera et al.
PHARMACOLOGY & THERAPEUTICS (2016)
Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction
Sophie J. Bradley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma
Veit J. Erpenbeck et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2016)
Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status
Huib A. M. Kerstjens et al.
RESPIRATORY MEDICINE (2016)
Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa
Kathila S. Rajapaksa et al.
TOXICOLOGICAL SCIENCES (2016)
Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma
Piotr Kuna et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2016)
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
Vernon Seow et al.
SCIENTIFIC REPORTS (2016)
Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial
James F. Donohue et al.
BMC PULMONARY MEDICINE (2016)
Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial
Paul M. O'Byrne et al.
LANCET RESPIRATORY MEDICINE (2016)
Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial
Sherif Gonem et al.
LANCET RESPIRATORY MEDICINE (2016)
In meso in situ In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures
Chia-Ying Huang et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2016)
Montelukast as an Alternative to Low-Dose Inhaled Corticosteroids in the Management of Mild Asthma (The SIMPLE Trial): An Open-Label Effectiveness Trial
R Andrew McIvor et al.
Canadian Respiratory Journal (2016)
Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy
David A. Sykes et al.
MOLECULAR PHARMACOLOGY (2016)
Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma
Loes E. M. Kistemaker et al.
RESPIRATORY RESEARCH (2016)
Long-acting muscarinic antagonists: a potential add-on therapy in the treatment of asthma?
William W. Busse et al.
EUROPEAN RESPIRATORY REVIEW (2016)
Depletion of major pathogenic cells in asthma by targeting CRTh2
Tao Huang et al.
JCI INSIGHT (2016)
Chemokine receptors and their therapeutic opportunities in diseased lung: Far beyond leukocyte trafficking
Tereza Tomankova et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)
'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models
Georges Vauquelin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
Leukotriene C4 induces bronchoconstriction and airway vascular hyperpermeability via the cysteinyl leukotriene receptor 2 in S-hexyl glutathione-treated guinea pigs
Yasuo Yonetomi et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
A summary of the new GINA strategy: a roadmap to asthma control
Helen K. Reddel et al.
EUROPEAN RESPIRATORY JOURNAL (2015)
Bronchodilating Drugs for Chronic Obstructive Pulmonary Disease: Current Status and Future Trends
Paolo Montuschi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Two disparate ligand-binding sites in the human P2Y1 receptor
Dandan Zhang et al.
NATURE (2015)
Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth
Nella Prevete et al.
PHARMACOLOGICAL RESEARCH (2015)
Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment
Ian P. Hall et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2015)
Efficacy of a new intravenous β2-adrenergic agonist (bedoradrine, MN-221) for patients with an acute exacerbation of asthma
Stacey L. House et al.
RESPIRATORY MEDICINE (2015)
The effect of fluticasone furoate/umeclidinium in adult patients with asthma: A randomized, dose-ranging study
Laurie A. Lee et al.
RESPIRATORY MEDICINE (2015)
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma
Polina L. Yarova et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling
Loes E. M. Kistemaker et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Pharmacotherapy for the treatment of asthma: current treatment options and future directions
Garret W. Choby et al.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2015)
Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction
Tomohiko Sekioka et al.
ALLERGOLOGY INTERNATIONAL (2015)
The role of leukotrienes in allergic diseases
Min Liu et al.
ALLERGOLOGY INTERNATIONAL (2015)
The histamine H4 receptor: from orphan to the clinic
Robin L. Thurmond
FRONTIERS IN PHARMACOLOGY (2015)
The relationship between allergen immunotherapy and omalizumab for treating asthma
Fulvio Braido et al.
EXPERT REVIEW OF RESPIRATORY MEDICINE (2015)
The Acute Management of Asthma
Timothy E. Albertson et al.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)
Long-Acting Beta Agonists Enhance Allergic Airway Disease
John M. Knight et al.
PLOS ONE (2015)
Recruitment of β-Arrestin 1 and 2 to the β2-Adrenoceptor: Analysis of 65 Ligands
Timo Littmann et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Eicosanoid storm in infection and inflammation
Edward A. Dennis et al.
NATURE REVIEWS IMMUNOLOGY (2015)
Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors
Luis E. Gimenez et al.
MOLECULAR PHARMACOLOGY (2015)
Type 2 cytokines: mechanisms and therapeutic strategies
Thomas A. Wynn
NATURE REVIEWS IMMUNOLOGY (2015)
Innate immunity is a key factor for the resolution of inflammation in asthma
Cindy Barnig et al.
EUROPEAN RESPIRATORY REVIEW (2015)
Potent and Efficacious Inhibition of CXCR2 Signaling by Biparatopic Nanobodies Combining Two Distinct Modes of Action
M. E. Bradley et al.
MOLECULAR PHARMACOLOGY (2015)
Type 2 inflammation in asthma - present in most, absent in many
John V. Fahy
NATURE REVIEWS IMMUNOLOGY (2015)
Salmeterol's Extreme β2 Selectivity Is Due to Residues in Both Extracellular Loops and Transmembrane Domains
Jillian G. Baker et al.
MOLECULAR PHARMACOLOGY (2015)
Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459
R. Pettipher et al.
ALLERGY (2014)
The Intrinsic Bias of Generalizations
Richard A. Bond
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Reply: Pharmacological Obfuscation of Clinical Relevance Reply
Shamsah Kazani et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Far from Disappointing
Raymond B. Penn
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Reply: Pharmacological Obfuscation of Clinical Relevance
Brian Lipworth et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Muscarinic M3 Receptors Contribute to Allergen-Induced Airway Remodeling in Mice
Loes E. M. Kistemaker et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)
Animal models of asthma: Reprise or reboot?
Kevin Mullane et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics
Z. Diamant et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2014)
Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma
Julia K. L. Walker et al.
CURRENT OPINION IN PHARMACOLOGY (2014)
Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development
Andrew C. Kruse et al.
CURRENT OPINION IN PHARMACOLOGY (2014)
Ligand bias prevents class equality among beta-blockers
Vaidehi J. Thanawala et al.
CURRENT OPINION IN PHARMACOLOGY (2014)
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
Jodie L. Simpson et al.
EUROPEAN RESPIRATORY JOURNAL (2014)
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung et al.
EUROPEAN RESPIRATORY JOURNAL (2014)
Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease
Clive Page et al.
EUROPEAN RESPIRATORY JOURNAL (2014)
Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4
James Edward Pease et al.
EXPERT OPINION ON DRUG DISCOVERY (2014)
Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs
Peter Norman
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)
Bedoradrine for treating asthma and chronic obstructive pulmonary disease
Sabina Antoniu
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)
Leukotriene receptor antagonists pranlukast and montelukast for treating asthma
Hiroto Matsuse et al.
EXPERT OPINION ON PHARMACOTHERAPY (2014)
Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation
Timotheus Y. F. Halim et al.
IMMUNITY (2014)
MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion
Christopher J. Oliphant et al.
IMMUNITY (2014)
Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis
Jinny E. Chang et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)
Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data
Wei Wu et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)
Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells
Luzheng Xue et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)
β-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent
Sarah J. Morgan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Animal Models of Allergic Airways Disease: Where Are We and Where to Next?
David G. Chapman et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2014)
First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Abediterol (LAS100977), a Novel Long-Acting β2-Agonist
Wolfgang Timmer et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2014)
Functional characterization of histamine H4 receptor on human mast cells
E. Angel Jemima et al.
MOLECULAR IMMUNOLOGY (2014)
Agonist-bound structure of the human P2Y12 receptor
Jin Zhang et al.
NATURE (2014)
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Kaihua Zhang et al.
NATURE (2014)
Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
Hye Young Kim et al.
NATURE MEDICINE (2014)
Muscarinic acetylcholine receptors: novel opportunities for drug development
Andrew C. Kruse et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Covalent agonists for studying G protein-coupled receptor activation
Dietmar Weichert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Abediterol (LAS100977), a novel long-acting β2-agonist: Efficacy, safety and tolerability in persistent asthma
J. Beier et al.
RESPIRATORY MEDICINE (2014)
The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide
Amadeu Gavalda et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2014)
Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis
Thor Seneca Thorsen et al.
STRUCTURE (2014)
GATA3: a master many trades in immune regulation
Yisong Y. Wan
TRENDS IN IMMUNOLOGY (2014)
Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
Yoshihide Kanaoka et al.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2014)
A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β2-adrenergic agonist, in asthma; a Phase II, randomized study
Dave Singh et al.
BMC PULMONARY MEDICINE (2014)
Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function
A. J. Theron et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2014)
Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study
Victor E. Ortega et al.
LANCET RESPIRATORY MEDICINE (2014)
Long-acting muscarinic receptor antagonists for the treatment of chronic airway diseases
Khuder Alagha et al.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2014)
Quantification of Ligand Bias for Clinically Relevant β2-Adrenergic Receptor Ligands: Implications for Drug Taxonomy
Emma T. van der Westhuizen et al.
MOLECULAR PHARMACOLOGY (2014)
Analysis of Histamine Receptor Knockout Mice in Models of Inflammation
Detlef Neumann et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
Structure based virtual screening of ligands to identify cysteinyl leukotriene receptor 1 antagonist
Srinivas Bandaru et al.
BIOINFORMATION (2014)
What Doesn't Kill May Not Make You Stronger β-Blockers for Asthma
Shamsah Kazani et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)
β2-Agonist Therapy in Lung Disease
Mario Cazzola et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)
Randomized Placebo-controlled Trial to Evaluate Chronic Dosing Effects of Propranolol in Asthma
Philip M. Short et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)
Antileukotriene Agents for the Treatment of Lung Disease
Jacob P. Scott et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)
Theophylline
Peter J. Barnes
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)
Nanobodies: Natural Single-Domain Antibodies
Serge Muyldermans
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82 (2013)
Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands
Georges Vauquelin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma
J. A. Schmidt et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Innate lymphoid cells and allergic inflammation
Brian S. Kim et al.
CURRENT OPINION IN IMMUNOLOGY (2013)
Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459
Dave Singh et al.
EUROPEAN RESPIRATORY JOURNAL (2013)
Effect of montelukast for treatment of asthma in cigarette smokers
David Price et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)
Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
William W. Busse et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)
Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation
Merritt L. Fajt et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)
Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growth in Vivo
David Maussang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4 Ligand
Yoshihide Kanaoka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Identification of 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968), a Potent, Selective, and Orally Bioavailable Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2) Antagonist
Heinz Fretz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Molecular Basis for the Long Duration of Action and Kinetic Selectivity of Tiotropium for the Muscarinic M3 Receptor
Christofer S. Tautermann et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Lead Optimization of Ethyl 6-Aminonicotinate Acyl Sulfonamides as Antagonists of the P2Y12 Receptor. Separation of the Antithrombotic Effect and Bleeding for Candidate Drug AZD1283
Peter Bach et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
Aaron M. Ring et al.
NATURE (2013)
Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression
Hiroyuki Hosokawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The expression and relaxant effect of bitter taste receptors in human bronchi
Stanislas Grassin-Delyle et al.
RESPIRATORY RESEARCH (2013)
Insights into mast cell functions in asthma using mouse models
Ying Lei et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2013)
Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD
Eric D. Bateman et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2013)
Bridging the gap: bitopic ligands of G-protein-coupled receptors
J. Robert Lane et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Molecular and cellular analysis of human histamine receptor subtypes
Roland Seifert et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation
Hiroki Kabata et al.
NATURE COMMUNICATIONS (2013)
Are inhaled longacting β2 agonists detrimental to asthma?
Donald W. Cockcroft et al.
LANCET RESPIRATORY MEDICINE (2013)
Innate lymphoid cells - how did we miss them?
Jennifer A. Walker et al.
NATURE REVIEWS IMMUNOLOGY (2013)
In Vitro Pharmacological Characterization of Vilanterol, a Novel Long-Acting beta(2)-Adrenoceptor Agonist with 24-Hour Duration of Action
Robert J. Slack et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery
Andrew C. Kruse et al.
MOLECULAR PHARMACOLOGY (2013)
Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases
Michael Salmon et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Effect of tiotropium bromide on airway remodeling in a chronic asthma model
Ji Young Kang et al.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2012)
The beta2-adrenergic receptor on T and B lymphocytes: Do we understand it yet?
Virginia M. Sanders
BRAIN BEHAVIOR AND IMMUNITY (2012)
Corticosteroids and β2-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms
M. Manetsch et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma
K. S. Buels et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
The Neutrophilic Inflammatory Phenotype Is Associated With Systemic Inflammation in Asthma
Lisa G. Wood et al.
CHEST (2012)
A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma
N. Barnes et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2012)
Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
P. Nair et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2012)
Cysteinyl leukotriene receptors, old and new; implications for asthma
T. M. Laidlaw et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2012)
Evaluation of Bedoradrine Sulfate (MN-221), a Novel, Highly Selective Beta2-Adrenergic Receptor Agonist for the Treatment of Asthma via Intravenous Infusion
Kazuko Matsuda et al.
JOURNAL OF ASTHMA (2012)
Leukotriene E4 Activates Human Th2 Cells for Exaggerated Proinflammatory Cytokine Production in Response to Prostaglandin D2
Luzheng Xue et al.
JOURNAL OF IMMUNOLOGY (2012)
Identification of Novel Adenosine A2A Receptor Antagonists by Virtual Screening
Christopher J. Langmead et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis
Roy Pettipher et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design
Miles Congreve et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Regulation of airway inflammation and remodeling by muscarinic receptors: Perspectives on anticholinergic therapy in asthma and COPD
Loes E. M. Kistemaker et al.
LIFE SCIENCES (2012)
Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients
A. Bellini et al.
MUCOSAL IMMUNOLOGY (2012)
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Kazuko Haga et al.
NATURE (2012)
Structure and dynamics of the M3 muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2012)
High-resolution crystal structure of human protease-activated receptor 1
Cheng Zhang et al.
NATURE (2012)
Asthma phenotypes: the evolution from clinical to molecular approaches
Sally E. Wenzel
NATURE MEDICINE (2012)
The potential of biologics for the treatment of asthma
Girolamo Pelaia et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
Yaozhong Zou et al.
PLOS ONE (2012)
Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4
Michael M. Mysinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation
Hideki Yasui et al.
RESPIRATORY MEDICINE (2012)
Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR
Jeffrey J. Liu et al.
SCIENCE (2012)
Pharmacological Characterization of Abediterol, a Novel Inhaled β2-Adrenoceptor Agonist with Long Duration of Action and a Favorable Safety Profile in Preclinical Models
Monica Aparici et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Pharmacology and Therapeutics of Bronchodilators
Mario Cazzola et al.
PHARMACOLOGICAL REVIEWS (2012)
Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils
Roy Pettipher et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Dose-response effects of TPI ASM8 in asthmatics after allergen
G. M. Gauvreau et al.
ALLERGY (2011)
Blocking the Leukotriene B4 Receptor 1 Inhibits Late-Phase Airway Responses in Established Disease
Koichi Waseda et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)
Targeting chemokine receptors in allergic disease
James E. Pease
BIOCHEMICAL JOURNAL (2011)
New perspectives regarding β2-adrenoceptor ligands in the treatment of asthma
J. K. L. Walker et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD
Bart C. Moulton et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Formoterol and salmeterol induce a similar degree of β2-adrenoceptor tolerance in human small airways but via different mechanisms
P. R. Cooper et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge
H. Imaoka et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2011)
The investigation of asthma phenotypes
Valerie Siroux et al.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2011)
Body mass index is associated with leukotriene inflammation in asthmatics
Paschalina Giouleka et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2011)
The cholinergic system in guttate psoriasis with special reference to mast cells
Julia Radosa et al.
EXPERIMENTAL DERMATOLOGY (2011)
Anti-mitogenic effects of beta-agonists and PGE(2) on airway smooth muscle are PKA dependent
Huandong Yan et al.
FASEB JOURNAL (2011)
Eosinophils Express Muscarinic Receptors and Corticotropin-Releasing Factor to Disrupt the Mucosal Barrier in Ulcerative Colitis
Conny Wallon et al.
GASTROENTEROLOGY (2011)
The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity
Bartosz J. Zieba et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Mucosal Allergic Sensitization to Cockroach Allergens Is Dependent on Proteinase Activity and Proteinase-Activated Receptor-2 Activation
Narcy G. Arizmendi et al.
JOURNAL OF IMMUNOLOGY (2011)
The Histamine H4 Receptor Is Highly Expressed on Plasmacytoid Dendritic Cells in Psoriasis and Histamine Regulates Their Cytokine Production and Migration
Maria Gschwandtner et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
THRX-198321 Is a Bifunctional Muscarinic Receptor Antagonist and β2-Adrenoceptor Agonist (MABA) That Binds in a Bimodal and Multivalent Manner
Tod Steinfeld et al.
MOLECULAR PHARMACOLOGY (2011)
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Soren G. F. Rasmussen et al.
NATURE (2011)
Structure and function of an irreversible agonist-β2 adrenoceptor complex
Daniel M. Rosenbaum et al.
NATURE (2011)
Crystal structure of the β2 adrenergic receptor-Gs protein complex
Soren G. F. Rasmussen et al.
NATURE (2011)
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
Jens Carlsson et al.
NATURE CHEMICAL BIOLOGY (2011)
Allosteric modulation of G protein-coupled receptors: A pharmacological perspective
Peter Keov et al.
NEUROPHARMACOLOGY (2011)
International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress
D. F. Woodward et al.
PHARMACOLOGICAL REVIEWS (2011)
Discovery of AMG 853, a CRTH2 and DP Dual Antagonist
Jiwen Liu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Interleukin-13 Signaling and Its Role in Asthma
Efren L. Rael et al.
WORLD ALLERGY ORGANIZATION JOURNAL (2011)
Both Hematopoietic-Derived and Non-Hematopoietic-Derived β-Arrestin-2 Regulates Murine Allergic Airway Disease
John W. Hollingsworth et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)
Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action
Georges Vauquelin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors
Jillian G. Baker
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Asthma and Allergic Inflammation
Richard M. Locksley
CELL (2010)
β-Adrenoceptor inverse agonists in asthma
Burton F. Dickey et al.
CURRENT OPINION IN PHARMACOLOGY (2010)
Response to salbutamol in patients with mild asthma treated with nadolol
N. A. Hanania et al.
EUROPEAN RESPIRATORY JOURNAL (2010)
The Constitutive Activity of the Human Muscarinic M3 Receptor Unmasks Differences in the Pharmacology of Anticholinergics
Paola Casarosa et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Conserved Binding Mode of Human β2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
Daniel Wacker et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders
Gregory J. Digby et al.
MOLECULAR BIOSYSTEMS (2010)
Call for withdrawal of LABA single-therapy inhaler in asthma
Richard Beasley et al.
LANCET (2010)
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
Kazuyo Moro et al.
NATURE (2010)
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill et al.
NATURE (2010)
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Michael P. Bokoch et al.
NATURE (2010)
Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
Deepak A. Deshpande et al.
NATURE MEDICINE (2010)
Divine Stramonium: The Rise and Fall of Smoking for Asthma
Mark Jackson
MEDICAL HISTORY (2010)
Systemically dispersed innate IL-13-expressing cells in type 2 immunity
April E. Price et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
Sven Jahnichen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates
Alexandra Hicks et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2010)
Montelukast: More than a Cysteinyl Leukotriene Receptor Antagonist?
Gregory R. Tintinger et al.
THESCIENTIFICWORLDJOURNAL (2010)
Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy
M. Weatherall et al.
THORAX (2010)
New therapies for asthma: is there any progress?
Peter J. Barnes
TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
Pharmacological Characterization of Olodaterol, a Novel Inhaled β2-Adrenoceptor Agonist Exerting a 24-Hour-Long Duration of Action in Preclinical Models
T. Bouyssou et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
How are TH2-type immune responses initiated and amplified?
William E. Paul et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Current Use of Beta Blockers in Patients With Reactive Airway Disease Who Are Hospitalized With Acute Coronary Syndromes
Benjamin A. Olenchock et al.
AMERICAN JOURNAL OF CARDIOLOGY (2009)
Drosophila in Asthma Research
Thomas Roeder et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma
Prescott G. Woodruff et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1
Samia Yazid et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Agonist-specific patterns of β2-adrenoceptor responses in human airway cells during prolonged exposure
Caroline Duringer et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Agonist efficacy and receptor desensitization: from partial truths to a fuller picture
Steven J. Charlton
BRITISH JOURNAL OF PHARMACOLOGY (2009)
On the mechanism of the persistent action of salmeterol: what is the current position?
R. A. Coleman
BRITISH JOURNAL OF PHARMACOLOGY (2009)
The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells
Anne-Marie Scola et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Molecular mechanisms for the persistent bronchodilatory effect of the beta(2)-adrenoceptor agonist salmeterol
A. Szczuka et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
The leukotriene E4 puzzle: Finding the missing pieces and revealing the pathobiologic implications
K. Frank Austen et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)
Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor
Sailaja Paruchuri et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Novel Function of CRTH2 in Preventing Apoptosis of Human Th2 Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway
Luzheng Xue et al.
JOURNAL OF IMMUNOLOGY (2009)
Investigation of β2-adrenoceptor subtype selectivity and organ specificity for bedoradrine (KUR-1246), a novel tocolytic beta-adrenergic receptor stimulant
Yoshihito Inoue et al.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2009)
Smoke, Choline Acetyltransferase, Muscarinic Receptors, and Fibroblast Proliferation in Chronic Obstructive Pulmonary Disease
Mirella Profita et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile
Amadeu Gavalda et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs
Paola Casarosa et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Hematopoietic Protein Tyrosine Phosphatase Mediates β2-Adrenergic Receptor-Induced Regulation of p38 Mitogen-Activated Protein Kinase in B Lymphocytes
Jaclyn W. McAlees et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
Hamida Hammad et al.
NATURE MEDICINE (2009)
Safety and Tolerability of Montelukast in Placebo-Controlled Pediatric Studies and Their Open-Label Extensions
Hans Bisgaard et al.
PEDIATRIC PULMONOLOGY (2009)
GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4
Akiko Maekawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Additional effects of pranlukast in salmeterol/fluticasone combination therapy for the asthmatic distal airway in a randomized crossover study
Hiroyuki Ohbayashi et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2009)
Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates
Rao V. Kalla et al.
PURINERGIC SIGNALLING (2009)
Effects of Pranlukast Hydrate on Airway Hyperresponsiveness in Non-Asthmatic Patients with Japanese Cedar Pollinosis
Hironori Sagara et al.
ALLERGOLOGY INTERNATIONAL (2009)
Histamine H4 receptors modulate dendritic cell migration through skin -: immunomodulatory role of histamine
W. Baeumer et al.
ALLERGY (2008)
Effect of β2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells:: a role for protein kinase A
Manminder Kaur et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
Gail M. Gauvreau et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)
Cluster analysis and clinical asthma phenotypes
Pranab Haldar et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)
Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesis
Akio Matsuda et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)
Risk for death associated with medications for recently diagnosed chronic obstructive pulmonary disease
Todd A. Lee et al.
ANNALS OF INTERNAL MEDICINE (2008)
The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses
R. Pettipher
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Modulation of mucus production by interleukin-13 receptor α2 in the human airway epithelium (vol 38, pg 382, 2008)
T. Tanabe et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2008)
Mouse models of allergic asthma: acute and chronic allergen challenge
Anthony T. Nials et al.
DISEASE MODELS & MECHANISMS (2008)
Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport
Michael P. W. Moos et al.
FASEB JOURNAL (2008)
β-arrestins specifically constrain β2-adrenergic receptor signaling and function in airway smooth muscle
Deepak A. Deshpande et al.
FASEB JOURNAL (2008)
Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease - A systematic review and meta-analysis
Sonal Singh et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2008)
Determinants of cytochrome P4502C8 substrate binding -: Structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid
Guillaume A. Schoch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
Laura McKinley et al.
JOURNAL OF IMMUNOLOGY (2008)
Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases
Elfatih Elzein et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
New targets for drug development in asthma
Ian M. Adcock et al.
LANCET (2008)
Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
Gary P. Anderson
LANCET (2008)
Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthmal
Raymond B. Penn
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2008)
Epac: effectors and biological functions
Sara S. Roscioni et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2008)
Pretreatment with albuterol versus montelukast for exercise-induced bronchospasm in children
Hengameh H. Raissy et al.
PHARMACOTHERAPY (2008)
Using guinea pigs in studies relevant to asthma and COPD
Brendan J. Canning et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2008)
The safety and effects of the beta-blocker, nadolol, in mild asthma: An open-label pilot study
Nicola A. Hanania et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2008)
A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor
Michael A. Hanson et al.
STRUCTURE (2008)
Montelukast as add-on therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: a systematic review
S. Joos et al.
THORAX (2008)
Biomedical applications of sheep models: from asthma to vaccines
Jean-Pierre Y. Scheerlinck et al.
TRENDS IN BIOTECHNOLOGY (2008)
β-Arrestin-biased Agonism at the β2-Adrenergic Receptor
Matthew T. Drake et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
β2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics
Jonathan D. Violin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Long-acting beta 2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells
Manminder Kaur et al.
MOLECULAR PHARMACOLOGY (2008)
Pharmacological characterization of indacaterol, a novel once daily inhaled beta(2) adrenoceptor agonist, on small airways in human and rat precision-cut lung slices
Richard G. Sturton et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Cyclooxygenase-2/prostaglandin D-2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation
Yoshiki Shiraishi et al.
JOURNAL OF IMMUNOLOGY (2008)
Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
Dominick E. Shaw et al.
CHEST (2007)
A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst
J. F. Royer et al.
ALLERGY (2007)
Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease:: preclinical and clinical developments
Alexandra Hicks et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2007)
Functional expression of H4 histamine receptor in human natural killer cells, monocytes, and dendritic cells
Bassam B. Damaj et al.
JOURNAL OF IMMUNOLOGY (2007)
High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
Vadim Cherezov et al.
SCIENCE (2007)
GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function
Daniel M. Rosenbaum et al.
SCIENCE (2007)
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
Soren G. F. Rasmussen et al.
NATURE (2007)
National asthma education and prevention program - Expert panel report 3 (EPR-3): Guidelines for the diagnosis and management of asthma - Summary report 2007
[Anonymous]
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)
CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene-dependent mitogenic responses of mast cells
Yongfeng Jiang et al.
BLOOD (2007)
Properties, production, and applications of camelid single-domain antibody fragments
M. M. Harmsen et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2007)
A unique mechanism of β-blocker action:: Carvedilol stimulates β-arrestin signaling
James W. Wisler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Genome-wide profiling identifies elpithelial cell genes associated with asthma and with treatment response to corticosteroids
Prescott G. Woodruff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease - GOLD executive summary
Klaus F. Rabe et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trends
Valerie Capra et al.
MEDICINAL RESEARCH REVIEWS (2007)
Corticosteroids and β2 Agonists differentially regulate rhinovirus-induced interleukin-6 via distinct cis-acting elements
Michael R. Edwards et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
Stephen C. Lazarus et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
Lena Uller et al.
RESPIRATORY RESEARCH (2007)
Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
Peter M. A. Calverley et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Salmeterol stimulation dissociates β2-adrenergic receptor phosphorylation and internalization
Robert H. Moore et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2007)
Combination therapy with a long-acting β-agonist and a leukotriene antagonist in moderate asthma
Aaron Deykin et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Effect of a specific and selective A(2B) adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma
S. Jamal Mustafa et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
beta-Agonist enhances type 2 T-cell survival and accumulation
Matthew J. Loza et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)
Allosteric modulation of muscarinic acetylcholine receptors
Karen J. Gregory et al.
CURRENT NEUROPHARMACOLOGY (2007)
Current concepts: The asthma epidemic
Waltraud Eder et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants
Shan L. Gyles et al.
IMMUNOLOGY (2006)
Distinct signaling profiles of β1 and β2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
Segolene Galandrin et al.
MOLECULAR PHARMACOLOGY (2006)
The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner
Georg Pongratz et al.
JOURNAL OF IMMUNOLOGY (2006)
Cutting edge: Interleukin 4-dependent mast cell proliferation requires Autocrine/Intracrine cysteinyl leukotriene-induced signaling
Yongfeng Jiang et al.
JOURNAL OF IMMUNOLOGY (2006)
β-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells
X. S. Wang et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2006)
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
Chun-Xiao Sun et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling
Berenice Herszberg et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
David Voehringer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Muscarinic receptor signaling in the pathophysiology of asthma and COPD
Reinoud Gosens et al.
RESPIRATORY RESEARCH (2006)
Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
PG Fallon et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2
JM Mathiesen et al.
MOLECULAR PHARMACOLOGY (2006)
Emerging roles of DP and CRTH2 in allergic inflammation
Evi Kostenis et al.
TRENDS IN MOLECULAR MEDICINE (2006)
CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation
Saula Ravasi et al.
RESPIRATORY RESEARCH (2006)
Role of anti-IgE monoclonal antibody (omalizumab) in the treatment of bronchial asthma and allergic respiratory diseases
G D'Amato
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Anticholinergic agents in asthma and COPD
NJ Gross
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells
MJ Loza et al.
BLOOD (2006)
Evidence of a role of tumor necrosis factor α in refractory asthma
MA Berry et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Corticosteroid effects on cell signalling
PJ Barnes
EUROPEAN RESPIRATORY JOURNAL (2006)
β-arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor
SK Shenoy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Muscarinic acetylcholine receptors
Masaru Ishii et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Role of adenosine in airway inflammation in an allergic mouse model of asthma
M Fan et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2006)
Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis
M. Peters-Golden et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2006)
Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells
LZ Xue et al.
JOURNAL OF IMMUNOLOGY (2005)
Characterization of isoprenaline- and salmeterol-stimulated interactions between β2-adrenoceptors and β-arrestin 2 using β-galactosidase complementation in C2C12 cells
AA Carter et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses
K Terawaki et al.
JOURNAL OF IMMUNOLOGY (2005)
The identification of the adenosine A2B receptor as a novel therapeutic target in asthma
ST Holgate
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness
N Miyahara et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)
Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators
J Jakubík et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells
R Gutzmer et al.
JOURNAL OF IMMUNOLOGY (2005)
Receptor-specific ubiquitination of β-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes
SK Shenoy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor
Y Shiraishi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors
JG Baker
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma
PM O'Byrne et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)
Synergy between A(2B) adenosine receptors and hypoxia in activating human lung fibroblasts
HY Zhong et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2005)
Inhaled beta(2)-adrenoceptor agonists cardiovascular safety in patients with obstructive lung disease
M Cazzola et al.
DRUGS (2005)
Effects of prostaglandin D2 on helper T cell functions
K Tanaka et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Effects of acute and chronic administration of β-adrenoceptor ligands on airway function in a murine model of asthma
Z Callaerts-Vegh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses
W Angeli et al.
JOURNAL OF IMMUNOLOGY (2004)
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
JC Hogg
LANCET (2004)
Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
B Min et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
RJ Lefkowitz
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation
AN Hata et al.
PHARMACOLOGY & THERAPEUTICS (2004)
A(2B)adenosine receptors increase cytokine release by bronchial smooth muscle cells
HY Zhong et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2004)
Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis
I Arai et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Adenosine-activated mast cells induce IgE synthesis by B lymphocytes:: An A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma
S Ryzhov et al.
JOURNAL OF IMMUNOLOGY (2004)
Asthma and cigarette smoking
NC Thomson et al.
EUROPEAN RESPIRATORY JOURNAL (2004)
Cardiovascular effects of β-agonists in patients with asthma and COPD -: A meta-analysis
SR Salpeter et al.
CHEST (2004)
Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice
TC Beller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of prostanoid DP receptor variants in susceptibility to asthma
T Oguma et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
An experimental model of allergic asthma in cats sensitized to house dust mite or Bermuda grass allergen
CRN Reinero et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2004)
Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands
XQ Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor
KF Buckland et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Prostaglandin D2 inhibits airway dentritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1
H Hammad et al.
JOURNAL OF IMMUNOLOGY (2003)
Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R
EA Mellor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Calcium-dependent and calcium-independent contractions in smooth muscles
KM Harnett et al.
AMERICAN JOURNAL OF MEDICINE (2003)
β-arrestin-2 regulates the development of allergic asthma
JKL Walker et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
The second PGD2 receptor CRTH2:: structure, properties, and functions in leukocytes
K Nagata et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2003)
Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells
CL Hofstra et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2003)
Cardiovascular safety of salmeterol in COPD
GT Ferguson et al.
CHEST (2003)
Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model
M Fan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)
Δ12-Prostaglandin J2, a plasma causes eosinophil mobilization metabolite of prostaglandin D2, from the bone marrow and primes eosinophils for chemotaxis
A Heinemann et al.
JOURNAL OF IMMUNOLOGY (2003)
CysLT1 receptor upregulation by TGF-β and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4
K Espinosa et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2003)
Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13
BB Vargaftig et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)
An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro
H Sugimoto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma
MJ Vaquerizo et al.
THORAX (2003)
Role of muscarinic receptor subtypes in the constriction of peripheral airways: Studies on receptor-deficient mice
N Struckmann et al.
MOLECULAR PHARMACOLOGY (2003)
Pranlukast - A review of its use in the management of asthma
SJ Keam et al.
DRUGS (2003)
Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma
E Huszár et al.
EUROPEAN RESPIRATORY JOURNAL (2002)
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
RH Green et al.
THORAX (2002)
Cyclic nucleotide research - still expanding after half a century
JA Beavo et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease
R Polosa
EUROPEAN RESPIRATORY JOURNAL (2002)
Update in clinical toxicology
J Chu et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)
Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses
A Maekawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
β-adrenoceptor agonists and asthma -: 100 years of development
B Waldeck
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils
C Bandeira-Melo et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2002)
Geometric determinants of airway resistance in two isomorphic rodent species
RFM Gomes et al.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2002)
Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism
L Fregonese et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2002)
Pharmacological differences among CysLT1 receptor antagonists with respect to LTC4 and LTD4 in human lung parenchyma
S Ravasi et al.
BIOCHEMICAL PHARMACOLOGY (2002)
Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor
M Nagata et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2002)
Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists
EA Mellor et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Pharmacological characterisation of the β-adrenoceptor expressed by human lung mast cells
LK Chong et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
R Casaburi et al.
EUROPEAN RESPIRATORY JOURNAL (2002)
CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice
JM Schuh et al.
JOURNAL OF IMMUNOLOGY (2002)
Identification of a histamine H4 receptor on human eosinophils -: Role in eosinophil chemotaxis
M O'Reilly et al.
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH (2002)
m3 muscarinic acetylcholine receptor regulation in the airway
CK Billington et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2002)
Allosteric site on muscarinic acetylcholine receptors: A single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands
S Buller et al.
MOLECULAR PHARMACOLOGY (2002)
A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model
WR Henderson et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)
Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients
Y Obase et al.
CHEST (2002)
Adenosine-mediated bronchoconstriction and lung inflammation in an allergic mouse model
M Fan et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2002)
Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP
FG Gervais et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2001)
Prostaglandins and leukotrienes: Advances in eicosanoid biology
CD Funk
SCIENCE (2001)
Remodeling in asthma and chronic obstructive lung disease
PK Jeffery
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)
Inhibition of human mast cell activation with the novel selective adenosine A2B receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)
I Feoktistov et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Sodium cromoglycate attenuates pulmonary inflammation without influencing bronchial responsiveness in healthy subjects exposed to organic dust
K Larsson et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2001)
Effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, combined with inhaled beclomethasone in patients with moderate or severe asthma
S Tomari et al.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2001)
Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase
L Spicuzza et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Basophil recruitment and IL-4 production during human allergen-induced late asthma
KT Nouri-Aria et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2001)
Distribution of hyoscyamine and scopolamine in Datura stramonium
E Miraldi et al.
FITOTERAPIA (2001)
Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy
JE Fish et al.
CHEST (2001)
Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients
Y Obase et al.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2001)
Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients
S Myou et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2001)
Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation
A Mathew et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Mechanisms of leukotriene D4-induced constriction in human small bronchioles
VA Snetkov et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Low-dose fluticasone propionate compared with montelukast for first-line treatment of persistent asthma: A randomized clinical trial
W Busse et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2001)
Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
H Hirai et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Zafirlukast - An update of its pharmacology and therapeutic efficacy in asthma
CJ Dunn et al.
DRUGS (2001)
Regulation and role of adenylyl cyclase isoforms
J Hanoune et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)
Effects of pranlukast, a leukotriene receptor antagonist, on airway inflammation in mild asthmatics
K Yamauchi et al.
JOURNAL OF ASTHMA (2001)
IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils
M Thivierge et al.
JOURNAL OF IMMUNOLOGY (2000)
Feline asthma - Diagnosis and treatment
P Padrid
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE (2000)
Crystal structure of rhodopsin: A G protein-coupled receptor
K Palczewski et al.
SCIENCE (2000)
The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor
J Takasaki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Stimulation of the B cell receptor, CD86 (B7-2), and the β2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell
DJ Kasprowicz et al.
JOURNAL OF IMMUNOLOGY (2000)
Montelukast added to inhaled beclomethasone in treatment of asthma
DA Stempel
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)
Effectiveness and tolerability of zafirlukast for the treatment of asthma in children
DS Pearlman et al.
CLINICAL THERAPEUTICS (2000)
Discovery and development of GS 4104 (oseltamivir): An orally active influenza neuraminidase inhibitor
W Lew et al.
CURRENT MEDICINAL CHEMISTRY (2000)
Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals
E Lee et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)
Prostaglandin D2 as a mediator of allergic asthma
T Matsuoka et al.
SCIENCE (2000)
β-adrenergic receptor blockade in chronic heart failure
MR Bristow
CIRCULATION (2000)
分享论文
