期刊
PEDIATRICS AND NEONATOLOGY
卷 61, 期 3, 页码 255-262出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.pedneo.2019.09.013
关键词
adolescents; bronchiectasis; children; chronic cough; suppurative lung disease
类别
Pediatric non-cystic fibrosis (CF) bronchiectasis is characterized by endobronchial suppuration, airway neutrophilic inflammation and poor mucus clearance and is associated with persistent productive cough due to recurrent airway infections. Most recommendations are based on expert opinion or extrapolated from CF practice. The present narrative review aims to address some issues on the management of children or adolescents with non CF-bronchiectasis that still require attention, and analyze what available literature offers to reply to open questions. We focused on the potential offered by technological advances on lung disease assessment through novel chest imaging techniques and new or old pulmonary function tests. We also summarized the main novelties in the disease prevention and treatment. Finally, a novel diagnostic algorithm is proposed, that might help physicians in the daily clinical decision-making process. Future directions for research on pediatric non-CF bronchiectasis should include larger study populations and longer prospective clinical trials, as well as new clinical and laboratory end-points to determine the underlying mechanisms of lung disease progression and support the role of new and existing treatments. Copyright (C) 2019, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.
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