期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 216, 期 1, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.prp.2019.152729
关键词
Stromal cell; Tumor microenvironment; Macrophage; Adipocyte; Fibroblast; Tumor evasion
类别
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- Programa de Pos-Graduacao em Ciencia Animal - Brasil (PPGCA)
Cancer is a disease that affects millions of individuals worldwide and has a great impact on public health. Therefore, the study of tumor biology and an understanding of how the components of the tumor microenvironment behave and interact is extremely important for cancer research. Factors expressed by the components of the tumor microenvironment and induce angiogenesis have important roles in the onset and progression of the tumor. These components are represented by the extracellular matrix, fibroblasts, adipocytes, immune cells, and macrophages, besides endothelial cells, which modulate tumor cells and the tumor microenvironment to favor survival and the progression of cancer. The characteristics and function of the main stromal components and their mechanisms of interaction with the tumor cells that contribute to progression, tumor invasion, and tumor spread will be addressed in this review. Furthermore, reviewing these components is expected to indicate their importance as possible prognostic markers and therapeutic targets.
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