期刊
PATHOBIOLOGY
卷 87, 期 2, 页码 61-74出版社
KARGER
DOI: 10.1159/000504055
关键词
Breast carcinoma; Tumour-infiltrating lymphocytes; Neoadjuvant chemotherapy; Tumour-infiltrating macrophages; Tumour-infiltrating neutrophils; Tumour-infiltrating dendritic cells; Pathological complete response
资金
- Ministry of Higher Education and Scientific Research, General Mission Sector (Egypt)
- Queen Elizabeth Hospital Birmingham Charity
- Birmingham CR-UK Centre
- Inflammatory Breast Cancer Network UK
The prognostic value of the immune cell infiltrate in the breast carcinoma microenvironment is still uncertain. We reviewed published articles analysing the infiltration of inflammatorycells in the microenvironment of breast carcinoma. Data revealed the importance of infiltration of these immune cells in the prognosis of breast carcinoma, particularly the triple-negative and HER2-positive phenotypes. Tumour-infiltrating lymphocytes and their subtypes play a fundamental role in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy. More research aiming to dissect a complex network of communication between cancer cells and other cellular components of the tumour microenvironment is necessary to develop more effective therapeutic approaches.
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