期刊
ORGANIC LETTERS
卷 21, 期 20, 页码 8469-8472出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03270
关键词
-
资金
- Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]
- National Science Fund for Distinguished Young Scholars [81725021]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- National Natural Science Foundation of China [21702067, 81573316]
Periconiastone A (1), an ergosterol with an unprecedented pentacyclo [8.7.0.0(1,5)0(2,14).0(10,15)]heptadecane system, was isolated from Periconia sp. TJ403-rc01. Its structure was assigned by extensive spectroscopic analyses and quantum-chemical C-13 NMR and ECD calculations. A vinylogous alpha-ketol rearrangement and an aldol condensation reaction during biosynthesis were proposed as key steps for the formation of 1. Compound 1 showed antibacterial activity against Gram-positive S. aureus and E. faecalis with MIC values of 4 and 32 mu g/mL, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据