期刊
ORGANIC LETTERS
卷 21, 期 23, 页码 9468-9472出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03666
关键词
-
资金
- Ministry of Science and Technology of the Republic of China [104-2628-M-003-001-MY3, 107-2113-M-003-014-MY3]
The asymmetric conjugate addition of arylboronic acids to N-phthalimidodehydroalanine 1i catalyzed by Rh(I)/L1a enables the facile preparation of chiral functionalized phenylalanines. The reaction proceeds by a conjugate addition and enantioselective protonation cascade, affording a rhodium enolate that undergoes re-face protonation. The reaction tolerates various arylboronic acids and can be used in the gram-scale synthesis of (S)-phenylalanine hydrochloride, demonstrating the reaction scope and the synthetic feasibility of the process.
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