期刊
ORGANIC LETTERS
卷 21, 期 23, 页码 9281-9285出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02644
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资金
- Indo-French Center for the Promotion of Advanced Research (IFCPAR/CEFIPRA) [5505-2]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE29-0012-01]
- Centre National de la Recherche Scientifique (CNRS)
- Agence Nationale de la Recherche (ANR) [ANR-15-CE29-0012] Funding Source: Agence Nationale de la Recherche (ANR)
This study discloses the first enantioselective variant of the gold(I)-catalyzed hydrative cyclizations of ynamides, which have been implemented by using bis-gold(I) complexes of chiral diphosphines. Starting from N-propargyl-ynamides and water in the presence of p-toluenesulfonic acid, the cyclization reactions afford N-tosyl-3,6-dihydropyridin-2(1H)-ones in good isolated yields and with high levels of stereocontrol (20 examples, enantiomeric ratios up to 94:6).
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