期刊
ORGANIC LETTERS
卷 21, 期 22, 页码 8966-8969出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03365
关键词
-
资金
- National Natural Science Foundation of China [21871212, 21402145]
- Natural Science Foundation of Hubei Province [2018CFB430]
- open foundation of CAS Key Laboratory of Molecular Recognition and Function
An efficient synthetic route to chiral allylic amines has been developed by nickel/(S,S)-Ph-BPE complex catalyzed chemoselective asymmetric hydrogenation of alpha,beta-unsaturated ketoimines. Varieties of alpha,beta-unsaturated ketoimines have been well tolerated in this transformation to give chiral allylic amines with high yields and excellent ee values (up to 99% yield, up to 99% ee). A gram-scale reaction with 0.2 mol % catalyst loading has also been achieved.
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