期刊
ORGANIC LETTERS
卷 21, 期 21, 页码 8824-8826出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03457
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资金
- Kobayashi Foundation
- JSPS KAKENHI [JP17K08345, JP19K16398]
- Showa Pharmaceutical University
Two new bromotyrosine alkaloids, ma'edamines C and D, were isolated from an Okinawan marine sponge Suberea sp. The structures of ma'edamines C and D were elucidated on the basis of spectroscopic data. Ma'edamines C and D were the first natural products possessing a unique tetrasubstituted pyridinium moiety such as N-alkyl-3,5-diethyl-2-propylpyridinium and N-alkyl-3,5-diethyl-4-propylpyridinium, respectively. Ma'edamines C and D exhibited moderate cytotoxicity against murine leukemia cell line L1210 in vitro.
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