期刊
ORGANIC LETTERS
卷 21, 期 22, 页码 9119-9123出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03509
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [26105721, 16H06217]
- Amano Institute of Technology scholarship
- Grants-in-Aid for Scientific Research [16H06217, 26105721] Funding Source: KAKEN
An asymmetric homoenolate cross-annulation of enals and aldehydes with high enantioselectivity is realized by NHC-catalyzed chemoselective umpolung of enals. The reaction proceeds in a highly chemoselective manner, selectively generating the conjugated Breslow intermediates from enals rather than aldehydes, enabling the homoenolate addition of enals to aldehydes in preference to competing acyl anion-mediated reactions. Enantioenriched substituted gamma-butyrolactones are formed in good yields with high enantioselectivities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据