Ni-Catalyzed Regioselective Hydroalkoxylation of Branched 1,3-Dienes

A highly regioselective Ni-catalyzed hydro-alkoxylation of 1,3-dienes is reported. The use of a (P,N) ligand is essential in achieving high levels of selectivity. The optimized protocol operates under particularly mild conditions, it provides access to a broad range of structurally diverse allylic ethers, and tolerates a number of sensitive functional groups.