期刊
ORGANIC LETTERS
卷 22, 期 1, 页码 1-5出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03434
关键词
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资金
- NIH-NIGMS [R01-GM117016]
- California Tobacco-Related Disease Research Program [28DT-0006]
- NSF [DGE-1144087, CHE-1048804]
- Foote Family
- University of California, Los Angeles
- NIH-NCRR [S10RR025631]
- Trueblood Family
Suzuki-Miyaura cross-couplings of amides offer an approach to the synthesis of ketones that avoids the use of basic or pyrophoric nucleophiles. However, these reactions require glovebox manipulations, thus limiting their practicality. We report a benchtop protocol for Suzuki- Miyaura cross-couplings of aliphatic amides that utilizes a paraffin capsule containing a Ni(0) precatalyst and NHC ligand. This methodology is broad in scope, is scalable, and provides a user-friendly approach to convert aliphatic amides to alkyl-aryl ketones.
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