期刊
ORGANIC LETTERS
卷 21, 期 21, 页码 8603-8606出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03189
关键词
-
资金
- NSF of China [21672075]
- Instrumental Analysis Center of Huaqiao University
We report a highly efficient copper-catalyzed three-component reaction of alkylamines, acetylenedicarboxylates, and alpha-bromocarbonyls for the assembly of fully substituted 1,3-dihydro-2H-pyrrol-2-ones. A variety of alkylamines and ammonium salt are functionalized with acetylenedicarboxylates and alpha-bromocarbonyls. N-aryl enam-inoesters are also successfully alkylated with alpha-bromocarbonyls. This protocol is understood to proceed through radical Heck-type coupling of in-situ-generated bulky trisubstituted alkenes with bulky tertiary alkyl bromides, which is realized for the first time.
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