期刊
ORGANIC LETTERS
卷 21, 期 21, 页码 8598-8602出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03188
关键词
-
资金
- Science and Engineering Research Board-DST, Government of India [EMR/2016/007021]
- CSIR
- IISc
N-Heterocyclic carbene (NHC)-catalyzed [3 + 3] annulation of thioamides with modified enals allowing the enantioselective synthesis of functionalized 1,3-thiazin-4-ones is reported. The NHC generated from the chiral triazolium salt was optimal and the reaction is initiated by the thia-Michael addition to catalytically generated alpha,beta-unsaturated acylazolium intermediates derived from 2-bromoenals, followed by intramolecular cyclization. This operationally simple procedure offers a straightforward and rapid access to target compounds in moderate to good yields and enantiomeric ratio values.
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