期刊
ORGANIC LETTERS
卷 21, 期 20, 页码 8383-8388出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03159
关键词
-
资金
- National Natural Science Foundation of China [21871292]
- Yunnan University
Treating chiral N-tert-butanesulfinyl ketimines with potassium hexamethyldisilazide (or potassium tert-butoxide) and methyl triflate gives N-methylated N-tert-butanesulfinyl enamine intermediates that undergo stereoselective [2,3]-rearrangement to afford alpha-sulfenyloxy ketones with excellent enantiopurities. This cascade of enamination-N-methylation rearrangement was even used to generate acyclic tertiary alpha-hydroxy ketones bearing two alpha-substituents showing negligible differences in bulkiness, such as methyl and ethyl groups.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据