期刊
ORGANIC LETTERS
卷 21, 期 21, 页码 8667-8672出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03282
关键词
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资金
- National Natural Science Foundation of China [21702139, 21971165]
- 1000-Youth Talents Program [YJ201702]
- Fundamental Research Funds for the Central Universities
Asymmetric multicomponent reactions toward optically pure compounds are highly attractive but extremely challenging. Presented herein is a highly diastereo- and enantioselective three-component cyclization of exocyclic alkenes with aldehydes and amino esters, which was enabled by bifunctional phosphonium salt catalysts. A wide range of multiply substituted spiro pyrrolidine derivatives were prepared in high yields with excellent stereoselectivities. Of note, this is the first example of a catalytic asymmetric three-component reaction with a phase-transfer catalysis system.
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