期刊
OCULAR SURFACE
卷 18, 期 2, 页码 335-344出版社
ELSEVIER
DOI: 10.1016/j.jtos.2019.10.006
关键词
Microbiome; Sjogren syndrome; Dysbiosis; dry eye; dry mouth
资金
- NIH/NEI [EY026893, EY002520]
- Alkek Center for Metagenomics and Microbiome Research
- Biology of Inflammation Center
- Research to Prevent Blindness Stein Innovation Award
- Research to Prevent Blindness (Department of Ophthalmology)
- The Oshman Foundation
- William Stamps Farish Fund
- The Hamill Foundation
- The Sid Richardson Foundation [P30CA125123]
- Baylor Cytometry and Cell Sorting Core [CPRIT Core Facility Support Award] [CPRIT-RP180672]
- Baylor Cytometry and Cell Sorting Core [P30 Cancer Center Support Grant] [NCI-CA125123, NIH-RR024574]
- Baylor Cytometry and Cell Sorting Core [NIH] [S10 OD025251]
- NATIONAL EYE INSTITUTE [P30EY002520] Funding Source: NIH RePORTER
The bacterial communities that collectively inhabit our body are called the microbiome. Virtually all body surface harbors bacteria. Recent advances in next-generation sequencing that have provided insight into the diversity, composition of bacterial communities, and their interaction are discussed in this review, as well as the current knowledge of how the microbiome promotes ocular health. The ocular surface is a site of low bacterial load. Sjogren Syndrome is an autoimmune disease that affects the exocrine glands, causing dry mouth and dry eye. Systemic antibiotic treatment and germ-free mice have demonstrated that commensal bacteria have a protective role for the ocular surface and lacrimal gland. The existence of a gut-eye-lacrimal gland axis-microbiome is discussed.
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