相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation
Vanessa C. Fernandes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
The Tumor Suppressor PALB2: Inside Out
Mandy Ducy et al.
TRENDS IN BIOCHEMICAL SCIENCES (2019)
Multiplex assessment of protein variant abundance by massively parallel sequencing
Kenneth A. Matreyek et al.
NATURE GENETICS (2018)
Accurate classification of BRCA1 variants with saturation genome editing
Gregory M. Findlay et al.
NATURE (2018)
Antiparallel Coiled-Coil Interactions Mediate the Homodimerization of the DNA Damage-Repair Protein PALB2
Fei Song et al.
BIOCHEMISTRY (2018)
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation
Marta Castroviejo-Bermejo et al.
EMBO MOLECULAR MEDICINE (2018)
Two Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein Interaction
Laura Caleca et al.
FRONTIERS IN ONCOLOGY (2018)
The Role of PALB2 in the DNA Damage Response and Cancer Predisposition
Thales C. Nepomuceno et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Coupling of Homologous Recombination and the Checkpoint by ATR
Remi Buisson et al.
MOLECULAR CELL (2017)
Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif
Joris Pauty et al.
NUCLEIC ACIDS RESEARCH (2017)
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk
T. K. Foo et al.
ONCOGENE (2017)
MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress
Jean-Yves Bleuyard et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation
Martijn S. Luijsterburg et al.
ELIFE (2017)
Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer
Natalia Paez Arango et al.
BREAST CANCER RESEARCH (2017)
REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants
Nilah M. Ioannidis et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2016)
M-CAP eliminates a majority of variants of uncertain significance in clinical exomes at high sensitivity
Karthik A. Jagadeesh et al.
NATURE GENETICS (2016)
Functional assays provide a robust tool for the clinical annotation of genetic variants of uncertain significance
Nicholas T. Woods et al.
NPJ GENOMIC MEDICINE (2016)
The PALB2 p.Leu939Trp mutation is not associated with breast cancer risk
Irene Catucci et al.
BREAST CANCER RESEARCH (2016)
Breast cancer risk in women with PALB2 mutations in diff erent populations
Antonis C. Antoniou et al.
LANCET ONCOLOGY (2015)
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
Raphael Ceccaldi et al.
NATURE (2015)
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
Pedro A. Mateos-Gomez et al.
NATURE (2015)
A mechanism for the suppression of homologous recombination in G1 cells
Alexandre Orthwein et al.
NATURE (2015)
Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing
Jordan Pinder et al.
NUCLEIC ACIDS RESEARCH (2015)
Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program
Malcolm A. Smith et al.
CLINICAL CANCER RESEARCH (2015)
Initial Testing (Stage 1) of the PARP Inhibitor BMN 673 by the Pediatric Preclinical Testing Program: PALB2 Mutation Predicts Exceptional In Vivo Response to BMN 673
Malcolm A. Smith et al.
PEDIATRIC BLOOD & CANCER (2015)
Exploring the roles of PALB2 at the crossroads of DNA repair and cancer
Joris Pauty et al.
BIOCHEMICAL JOURNAL (2014)
Breast-Cancer Risk in Families with Mutations in PALB2
A. C. Antoniou et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair
J-Y Park et al.
ONCOGENE (2014)
Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase h in Recombination-Associated DNA Synthesis at Blocked Replication Forks
Remi Buisson et al.
CELL REPORTS (2014)
Identifying Mendelian disease genes with the Variant Effect Scoring Tool
Hannah Carter et al.
BMC GENOMICS (2013)
BMN673, a Novel and Highly Potent PARP1/2 Inhibitor for the Treatment of Human Cancers with DNA Repair Deficiency
Yuqiao Shen et al.
CLINICAL CANCER RESEARCH (2013)
RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination
B. H. Lok et al.
ONCOGENE (2013)
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
Jean-Yves Bleuyard et al.
EMBO REPORTS (2012)
PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function
Jianglin Ma et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
PALB2 self-interaction controls homologous recombination
Remi Buisson et al.
NUCLEIC ACIDS RESEARCH (2012)
A Computational Method to Classify Variants of Uncertain Significance Using Functional Assay Data with Application to BRCA1
Edwin S. Iversen et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2011)
A novel germline PALB2 deletion in Polish breast and ovarian cancer patients
Agnieszka Dansonka-Mieszkowska et al.
BMC MEDICAL GENETICS (2010)
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks
Tomohiro Hayakawa et al.
JOURNAL OF CELL SCIENCE (2010)
A method and server for predicting damaging missense mutations
Ivan A. Adzhubei et al.
NATURE METHODS (2010)
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination
Remi Buisson et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2
Eloiese Dray et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response
Feng Zhang et al.
CURRENT BIOLOGY (2009)
Structural basis for recruitment of BRCA2 by PALB2
Antony W. Oliver et al.
EMBO REPORTS (2009)
MRG15 Is a Novel PALB2-interacting Factor Involved in Homologous Recombination
Shirley M. -H. Sy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization
Shirley M. -H. Sy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2
Fan Zhang et al.
MOLECULAR CANCER RESEARCH (2009)
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
Shirley M. H. Sy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Sian Jones et al.
SCIENCE (2009)
Analysis of PALB2/FANCN-associated breast cancer families
Marc Tischkowitz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A recurrent mutation in PALB2 in Finnish cancer families
Hannele Erkko et al.
NATURE (2007)
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
Bing Xia et al.
NATURE GENETICS (2007)
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
Sarah Reid et al.
NATURE GENETICS (2007)
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
Nazneen Rahman et al.
NATURE GENETICS (2007)
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2
Bing Xia et al.
MOLECULAR CELL (2006)
Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods
E Mathe et al.
NUCLEIC ACIDS RESEARCH (2006)
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
HE Bryant et al.
NATURE (2005)
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer et al.
NATURE (2005)
分享论文
