4.2 Article

Bladder and urethral dysfunction in multiparous and mature rabbits correlates with abnormal activity of pubococcygeus and bulbospongiosus muscles

期刊

NEUROUROLOGY AND URODYNAMICS
卷 39, 期 1, 页码 116-124

出版社

WILEY
DOI: 10.1002/nau.24176

关键词

bulbospongiosus; cystometrograms; intraurethral; pubococcygeus; stress urinary incontinence

资金

  1. Direccion General de Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico [PAPIIT-IN212916]

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Aims To evaluate the combined effect of age and multiparity on the micturition reflex, including pelvic floor muscle activation. Methods Young and mature nulliparous rabbits were compared to young and mature multiparas (n = 6 per group). Cystometrograms and urethral pressure (UP) were performed while simultaneously recording the electromyogram (EMG) activity of the pubococcygeus and bulbospongiosus muscles to establish their functional correlation to urological function. Results Multiparity and age significantly influence the bladder and UP affecting the voiding efficiency and intercontraction interval. Such interaction also reduced the UP threshold, timing, and duration. Other bladder and urethral variables were predominantly affected only by age. Urodynamic alterations correlated with abnormal patterns or absent EMG activity of the pubococcygeus and bulbospongiosus muscles. Conclusions The present findings strongly suggest that multiparity and age affects specific pelvic floor muscle reflex activation during micturition, and may contribute to alterations in bladder and urethral function. This data broadens our understanding of the critical role of the appropriate activity of the individual pelvic floor muscles in micturition.

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