期刊
NEUROSCIENCE
卷 447, 期 -, 页码 167-181出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2019.10.021
关键词
astrocyte; microglia; inflammation; obesity; diabetes; immunometabolism
资金
- Medical Research Council [MR/N012763/1]
- Diabetes UK (RD Lawrence Fellowship) [13/0004647]
- European Foundation for the Study of Diabetes
- University of Exeter Medical School
- MRC [MR/N012763/1] Funding Source: UKRI
Chronic low-grade inflammation is a feature of the pathophysiology of obesity and diabetes in the CNS as well as peripheral tissues. Glial cells are critical mediators of the response to inflammation in the brain. Key features of glia include their metabolic flexibility, sensitivity to changes in the CNS microenvironment, and ability to rapidly adapt their function accordingly. They are specialised cells which cooperate to promote and preserve neuronal health, playing important roles in regulating the activity of neuronal networks across the brain during different life stages. Increasing evidence points to a role of glia, most notably astrocytes and microglia, in the systemic regulation of energy and glucose homeostasis in the course of normal physiological control and during disease. Inflammation is an energetically expensive process that requires adaptive changes in cellular metabolism and, in turn, metabolic intermediates can also have immunomodulatory actions. Such immunometabolic changes in peripheral immune cells have been implicated in contributing to disease pathology in obesity and diabetes. This review will discuss the evidence for a role of immunometabolic changes in glial cells in the systemic regulation of energy and glucose homeostasis, and how this changes in the context of obesity and diabetes. This article is part of a Special Issue entitled: The Neuroscience of Energy Balance and Eating Behavior (C) 2020 The Authors. Published by Elsevier Ltd on behalf of IBRO.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据