期刊
NEURON
卷 105, 期 1, 页码 75-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2019.10.008
关键词
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资金
- NIH [NIMH 1R01MH110553]
- Pediatric Epilepsies Award (Citizens United for Research in Epilepsy)
- Leon Levy Fellowship Award (Leon Levy Foundation)
- Frueauff Foundation Award
- NIMH [1R01MH109685, 1R01MH118451]
- European Research Council Horizon H2020 [646925]
- Horizon 2020 MSCA-IF-2014 [660795]
- French National Research Agency [ANR-14-CE13-0016]
- Whitehall Foundation
- NIGMS [5F30MH117939, 5F30MH115622, T32GM007739]
During neonatal development, sensory cortices generate spontaneous activity patterns shaped by both sensory experience and intrinsic influences. How these patterns contribute to the assembly of neuronal circuits is not clearly understood. Using longitudinal in vivo calcium imaging in un-anesthetized mouse pups, we show that spatially segregated functional assemblies composed of interneurons and pyramidal cells are prominent in the somatosensory cortex by postnatal day (P) 7. Both reduction of GABA release and synaptic inputs onto pyramidal cells erode the emergence of functional topography, leading to increased network synchrony. This aberrant pattern effectively blocks interneuron apoptosis, causing increased survival of parvalbumin and somatostatin interneurons. Furthermore, the effect of GABA on apoptosis is mediated by inputs from medial ganglionic eminence (MGE)-derived but not caudal ganglionic eminence (CGE)-derived interneurons. These findings indicate that immature MGE interneurons are fundamental for shaping GABA-driven activity patterns that balance the number of interneurons integrating into maturing cortical networks.
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