期刊
NEURON
卷 105, 期 1, 页码 138-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2019.10.012
关键词
-
资金
- NIH [MH54671, MH107396, U19 NS107616, U19 NS104590, NS090583]
- NSF PIRE grant [1545858]
- Simons Foundation [351109]
- Office Of Internatl Science &Engineering [1545858] Funding Source: National Science Foundation
- Office Of The Director [1545858] Funding Source: National Science Foundation
The mnemonic functions of hippocampal sharp wave ripples (SPW-Rs) have been studied extensively. Because hippocampal outputs affect not only cortical but also subcortical targets, we examined the impact of SPW-Rs on the firing patterns of lateral septal (LS) neurons in behaving rats. A large fraction of SPW-Rs were temporally locked to high-frequency oscillations (HFOs) (120-180 Hz) in LS, with strongest coupling during non-rapid eye movement (NREM) sleep, followed by waking immobility. However, coherence and spike-local field potential (LFP) coupling between the two structures were low, suggesting that HFOs are generated locally within the LS GABAergic population. This hypothesis was supported by optogenetic induction of HFOs in LS. Spiking of LS neurons was largely independent of the sequential order of spiking in SPW-Rs but instead correlated with the magnitude of excitatory synchrony of the hippocampal output. Thus, LS is strongly activated by SPW-Rs and may convey hippocampal population events to its hypothalamic and brainstem targets.
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