期刊
NATURE PHOTONICS
卷 14, 期 2, 页码 109-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41566-019-0536-x
关键词
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资金
- Caltech Innovation Initiative programe
- Ilju organization
Quantitative phase imaging (QPI) of transparent samples plays an essential role in multiple biomedical applications, and miniaturizing these systems will enable their adoption into point-of-care and in vivo applications. Here, we propose a compact quantitative phase gradient microscope (QGPM) based on two dielectric metasurface layers, inspired by a classical differential interference contrast (DIC) microscope. Owing to the multifunctionality and compactness of the dielectric metasurfaces, the QPGM simultaneously captures three DIC images to generate a quantitative phase gradient image in a single shot. The volume of the metasurface optical system is on the order of 1 mm(3). Imaging experiments with various phase resolution samples verify the capability to capture quantitative phase gradient data, with phase gradient sensitivity better than 92.3 mrad mu m(-1) and single-cell resolution. The results showcase the potential of metasurfaces for developing miniaturized QPI systems for label-free cellular imaging and point-of-care devices. Using two dielectric metasurface layers, a compact quantitative phase gradient microscope that can capture quantitative phase gradient images in a single shot is reported with phase gradient sensitivity better than 92.3 mrad mu m(-1) and single-cell resolution.
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