期刊
NATURE IMMUNOLOGY
卷 20, 期 11, 页码 1456-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-019-0518-7
关键词
-
类别
资金
- Canadian Institutes of Health Research [MOP-119538, FND-154332]
- National Institutes of Health [NIH-1P01AI102853-01]
- Krembil Foundation
- Ontario Graduate Scholarship
- Banting and Best Doctoral Research Award
- Canada Research Chair in Developmental Immunology
T cell specification and commitment require Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is known, it is still unclear whether the onset of T cell priming can occur in a prethymic niche and whether RBPJ-dependent Notch signaling has a role during this event. Here, we established an Rbpj-inducible system that allowed temporal and tissue-specific control of the responsiveness to Notch in all hematopoietic cells. Using this system, we found that Notch signaling was required before the early T cell progenitor stage in the thymus. Lymphoid-primed multipotent progenitors in the bone marrow underwent Notch signaling with Rbpj induction, which inhibited development towards the myeloid lineage in thymus-seeding progenitors. Thus, our results indicated that the onset of T cell differentiation occurred in a prethymic setting, and that Notch played an important role during this event.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据