期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 22, 页码 4211-4217出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1689498
关键词
Actinomycete; Verrucosispora; antibiotics; antimicrobial activity; Helicobacter pylori
资金
- National Key R&D Program of China [2018YFC0311001]
- Drug Innovation Major Project [2018ZX0971001-007-007]
The actinomycete strain FIM06-0036 was isolated from a marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. It produced a new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate, as well as a known alkaloid butyl 1H-imidazole-4-carboxylate, both of which showed antimicrobial activity against various bacteria.
The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate (1), together with a known alkaloid butyl 1H-imidazole-4-carboxylate (2) was obtained from the fermentation products of this strain, the structures of compounds 1 and 2 were determined by their detailed analysis of 1 D, 2 D NMR and HR-ESI-MS data, along with literature data analysis. Compounds 1 and 2 were evaluated for their antimicrobial activity with MIC (minimum inhibitory concentration) values ranging from 8 to 256 mu g center dot mL(-1) against Helicobacter pylori, Klebsiella Pneumonia, Staphylococcus aureus and Enterococcus faecalis.
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