期刊
NATURAL PRODUCT COMMUNICATIONS
卷 14, 期 10, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X19862647
关键词
Cephalaria tuteliana; Caprifoliaceae; saponin; cytotoxic activity; immunomodulatory activity
资金
- Research Grant Office of Ege University [2017/Fen/072]
Phytochemical investigation of Cephalaria tuteliana (Caprifoliaceae) endemic to Turkey was carried out for the first time. Thirteen compounds were isolated, including 2 triterpenoid sapogenins, 10 saponins, and 1 iridoid glycoside. This is the first report of the isolation of pomolic acid, tormentic acid, and 3-O-alpha-L-rhamnopyranosyl-(1 -> 3)-beta-D-glucopyranosyl hederagenin, not only from the Cephalaria genus, but also from the Caprifoliaceae family. The structures of the isolated compounds were elucidated by a combination of spectroscopy, including one- and two-dimensional nuclear magnetic resonance, and by comparison with the reported data in the literature. Two triterpene sapogenins, hederagenin and oleanoic acid, the latter being the most typical sapogenin of the oleanane type of triterpene saponins, were evaluated by the MTT method for their cytotoxic effect against A549, HeLa, PANC1, and SHSY5Y cancer cells, and the noncancerous HEK293 cell line. The cytotoxic activity of triterpene aglycones was discussed in detail and a structure-activity relationship was established. C. tuteliana may be considered as a useful source for developing new cytotoxic and immunotherapeutic agents due to its biologically active saponin content.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据