期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 21, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2019.102040
关键词
Mesoporous silica coated magnetic nanoparticles; Mesenchymal stem cells; Large bone defects; Distraction osteogenesis; Bone regeneration
资金
- National Natural Science Foundation of China [81802156, 81772338, 81571729, 81572121]
- Interdisciplinary Program of Shanghai Jiao Tong University, China [YG2017ZD05]
- Shanghai Leading Talent Plan, China [043]
Distraction osteogenesis (DO) represents an effective but undesirably lengthy treatment for large bone defects. Both magnetic nanoparticles and silicon have been shown to induce osteogenic differentiation of mesenchymal stem cells (MSCs), the key participant in bone regeneration. We herein synthesized mesoporous silica coated magnetic (Fe3O4) nanoparticles (M-MSNs) and evaluated its potential for acceleration of bone regeneration in a rat DO model. The M-MSNs exhibited good biocompatibility and remarkable capability in promoting the osteogenic differentiation of MSCs via the canonical Wnt/beta-catenin pathway in vitro. More importantly, local injection of M-MSNs dramatically accelerated bone regeneration in a rat DO model according to the results of X-ray imaging, micro-CT, mechanical testing, histological examination, and immunochemical analysis. This study demonstrates the notable potential of M-MSNs in promoting bone regeneration during DO by enhancing the osteogenic differentiation of MSCs, paving the way for clinical translation of M-MSNs in DO to repair large bone defects. (C) 2019 Elsevier Inc. All rights reserved.
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