期刊
NANO LETTERS
卷 19, 期 11, 页码 7836-7844出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b02841
关键词
Microfluidics; biomimetic nanoparticles; exosomes; targeting; immune evasion
类别
资金
- National Natural Science Foundation of China [21622503]
- Scientific Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20180055]
- Youth Innovation Promotion Association CAS [2016035]
Using natural membranes to coat nanoparticles (NPs) provides an efficient means to reduce the immune clearance of NPs and improve their tumor-specific targeting. However, fabrication of these drug-loaded biomimetic NPs, such as exosome membrane (EM)- or cancer cell membrane (CCM)-coated poly(lactic-co-glycolic acid) (PLGA) NPs, remains a challenging task owing to the heterogeneous nature of biomembranes and labor-intensive procedures. Herein, we report a microfluidic sonication approach to produce EM-, CCM-, and lipid-coated PLGA NPs encapsulated with imaging agents in a one-step and straightforward manner. Tumor cell-derived EM-coated PLGA NPs consisting of both endosomal and plasma membrane proteins show superior homotypic targeting as compared to CCM-PLGA NPs of similar sizes and core-shell structures in both in vitro and in vivo models. The underlying mechanism is associated with a significantly reduced uptake of EM-PLGA NPs by macrophages and peripheral blood monocytes, revealing an immune evasion-mediated targeting of EM-PLGA NPs to homologous tumors. Overall, this work illustrates the promise of using microfluidic sonication approach to fabricate biomimetic NPs for better biocompatibility and targeting efficacy.
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