期刊
NANO LETTERS
卷 19, 期 12, 页码 8409-8417出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b02448
关键词
Biodegradable silica; framework swelling enhanced photothermal effect; debris-mediated immunostimulation
类别
资金
- National Natural Science Foundation of China [31922044, 81573002, 21675032, 81861138040, 81773280]
- Shanghai Pujiang Program [17PJD002]
- Natural Science Foundation of Shanghai [19ZR1471600]
- Fundamental Research Funds for the Central Universities
- Original Support Program of Fudan University [XM03180307]
- Minhang Hospital Collaboration Fund [RO-MY201802]
- DHU Distinguished Young Professor Program
Incorporating carbon nanodots (CDs) into mesoporous silica framework for extensive biomedicine, especially for the desirable cancer immunotherapy, is considered to be an unexplored challenge. Herein, a hydrogen bond/electrostatic-assisted co-assembly strategy was smartly exploited to uniformly incorporate polymer-coated CDs into ordered framework of mesoporous silica nanoparticles (CD@MSNs). The obtained CD@MSN was not only biodegradable via the framework-incorporated CD-induced swelling but also capable of gathering dispersive CDs with enhanced photothermal effect and elevated targeting accumulation, which therefore can achieve photothermal imaging-guided photothermal therapy (PTT) in vitro and in vivo. Interestingly, benefiting from the biodegraded debris, it was found that CD@MSN-mediated PTT can synergistically achieve immune-mediated inhibition of tumor metastasis via stimulating the proliferation and activation of natural killer cells and macrophages with simultaneously up-regulating the secretion of corresponding cytokines (IFN-gamma and Granzyme B). This work proposed an unusual synthesis of biodegradable mesoporous silica and provided an innovative insight into the biodegradable nanoparticles-associated anticancer immunity.
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